LOCUS       SIT99554.1               370 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PERIPLASMIC
            PHOSPHATE-BINDING LIPOPROTEIN PSTS2 (PBP-2) (PSTS2) protein.
ACCESSION   LT708304-966
PROTEIN_ID  SIT99554.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pstS2"
                     /locus_tag="BQ2027_MB0956C"
                     /note="Mb0956c, pstS2, len: 370 aa. Equivalent to Rv0932c,
                     len: 370 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 370 aa overlap). pstS2,
                     phosphate-binding lipoprotein component of inorganic
                     phosphate transport system (see citations below), highly
                     similar to AAF74819.1|AF137360_1|AF137360 periplasmic
                     phosphate permease from Mycobacterium avium (369 aa);
                     Rv0928|MTCY21C12.22|pstS3 PHOSPHATE-BINDING PERIPLASMIC
                     LIPOPROTEIN from Mycobacterium tuberculosis (370 aa),
                     FASTA scores: opt: 1601, E(): 0, (64.5% identity in 372 aa
                     overlap); and Rv0934|MTCY08D9.05c|pstS1 PHOSPHATE-BINDING
                     PERIPLASMIC LIPOPROTEIN from Mycobacterium tuberculosis
                     (374 aa) (M. tuberculosis seems to have three PstS-like
                     proteins, others being Rv0928 and Rv0934c). Also highly
                     similar to MTCY08D9.05c|P15712|PAB_MYCTU PROTEIN ANTIGEN B
                     PRECURSOR from Mycobacterium tuberculosis (374 aa), FASTA
                     scores: opt: 460, E(): 2.7e-20, (31.2% identity in 375 aa
                     overlap). Contains prokaryotic membrane lipoprotein lipid
                     attachment site (PS00013) at N-terminus so the leader
                     peptide of 22 aa is probably removed. BELONGS TO FAMILY OF
                     PHOSPHATE RECEPTORS FOR BACTERIAL ABC-TYPE LIPOPROTEIN
                     TRANSPORTERS. Appears to be co-transcribed with
                     Rv0931c|pknD|mbk. Protein product from Mb0956c detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0956c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XWW7"
                     /db_xref="InterPro:IPR005673"
                     /db_xref="InterPro:IPR024370"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XWW7"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MKFARSGAAV SLLAAGTLVL TACGGGTNSS SSGAGGTSGS VHCGGKKELH SSGSTAQENA
       61 MEQFVYAYVR SCPGYTLDYN ANGSGAGVTQ FLNNETDFAG SDVPLNPSTG QPDRAAERCG
      121 SPAWDLPTVF GPIAITYNIK GVSTLNLDGP TTAKIFNGTI TVWNDPQIQA LNSGTDLPPT
      181 PISVIFRSDK SGTSDNFQKY LDGASNGAWG KGASETFNGG VGVGASGNNG TSALLQTTDG
      241 SITYNEWSFA VGKQLNMAQI ITSAGPDPVA ITTESVGKTI AGAKIMGQGN DLVLDTSSFY
      301 RPTQPGSYPI VLATYEIVCS KYPDATTGTA VRAFMQAAIG PGQEGLDQYG SIPLPKSFQA
      361 KLAAAVNAIS
//