LOCUS       SIT99548.1               263 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            short-chain type dehydrogenase/reductase protein.
ACCESSION   LT708304-960
PROTEIN_ID  SIT99548.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0950C"
                     /note="Mb0950c, -, len: 263 aa. Equivalent to Rv0927c,
                     len: 263 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 263 aa overlap). Probable short-chain
                     dehydrogenase/reductase (EC 1.-.-.-), similar to various
                     dehydrogenases/reductases, notably 7-alpha-hydroxysteroid
                     dehydrogenases and glucose 1-dehydrogenases e.g.
                     P25529|HDHA_ECOLI 7-alpha-hydroxysteroid dehydrogenase
                     from Escherichia coli (255 aa), FASTA scores: opt: 551,
                     E(): 1e-26, (39.5% identity in 248 aa overlap);
                     NP_252778.1|NC_002516 probable short-chain dehydrogenase
                     from Pseudomonas aeruginosa (253 aa); AAC44307.1|U59433
                     3-ketoacyl-acyl carrier protein reductase from Bacillus
                     subtilis (246 aa); etc. Also similar to other
                     dehydrogenases from Mycobacterium tuberculosis e.g.
                     MTCY09F9.36, E():1.4e-18; MTCY369.14, E():8e-17;
                     MTCY02B10.14, E():2.5e-14; MTCY09F9.23c, E():1.5e-13;
                     MTCY03C7.07, E():1.9e-13. Contains PS00061 Short-chain
                     dehydrogenases/reductases family signature, and PS00017
                     ATP/GTP-binding site motif A (P-loop). BELONGS TO THE
                     SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY.
                     Protein product from Mb0950c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0950c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XWT1"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR020904"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XWT1"
BEGIN
        1 MILDMFRLDD KVAVITGGGR GLGAAIALAF AQAGADVLIA SRTSSELDAV AEQIRAAGRR
       61 AHTVAADLAH PEVTAQLAGQ AVGAFGKLDI VVNNVGGTMP NTLLSTSTKD LADAFAFNVG
      121 TAHALTVAAV PLMLEHSGGG SVINISSTMG RLAARGFAAY GTAKAALAHY TRLAALDLCP
      181 RVRVNAIAPG SILTSALEVV AANDELRAPM EQATPLRRLG DPVDIAAAAV YLASPAGSFL
      241 TGKTLEVDGG LTFPNLDLPI PDL
//