LOCUS SIT99536.1 412 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE LIPID CARRIER PROTEIN OR KETO ACYL-COA THIOLASE protein. ACCESSION LT708304-948 PROTEIN_ID SIT99536.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB0938C" /note="Mb0938c, -, len: 412 aa. Equivalent to Rv0914c, len: 412 aa, from Mycobacterium tuberculosis strain H37Rv, (100% identity in 412 aa overlap). Possible lipid carrier protein or keto acyl-CoA thiolase (EC 2.3.1.16), highly similar to NP_421905.1|NC_002696 thiolase family protein from Caulobacter crescentus (407 aa); and similar to others e.g. NP_107896.1|NC_002678 3-ketoacyl-CoA thiolase from Mesorhizobium loti (392 aa); NP_385796.1|NC_003047 PUTATIVE 3-KETOACYL-COA THIOLASE PROTEIN from Sinorhizobium meliloti (389 aa); NP_275932.1|NC_000916 lipid-transfer protein (sterol or nonspecific) from Methanothermobacter thermautotrophicus (383 aa); AB55378.1|AL117263 possible 3-ketoacyl-CoA thiolase from Leishmania major (441 aa), FASTA scores: opt: 547, E(): 3.1e-26, (31.0% identity in 435 aa overlap); etc. Also similar to Rv2790c, Rv1627c, Rv0244, etc from Mycobacterium tuberculosis. COULD BELONG TO THE THIOLASE FAMILY. Protein product from Mb0938c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb0938c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XWT3" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="UniProtKB/TrEMBL:A0A1R3XWT3" BEGIN 1 MDDGVWILGG YQSDFARNLS KENRDFADLT REVVDGTLTA AKVDAADLAA AGVVHVANAF 61 GEMFARQGHL GAMPATVCDD LWDTPATRHE AACASGSVAT LAAMADLRSG AYRVALVVGL 121 ELEKTVPGDT AAEHLSAAAW TGHEGAEARY LWPSMFAQVA DEYDRRYGLD DTHLRAIAQL 181 NFANARRNPN AQTRGWTIPD PITDDDATNP LTEGRLRRFD CSQMTDGGAG LVLVSDAYLR 241 DHRDARPIGR IDGWGHRTVG LGLRQKLDRV AQGDSAPYLL PHVRATVLDA LRRARVTLDD 301 LDGIEVHDCF TPSEYLAIDH IGLTGPGESW KAIENGEIEI GGRLPINPSG GLIGGGHPVG 361 ASGVRMLLDA AKQVSGIAGD YQVENAEAFG TLNFGGSTAT TVSFVVSTTR GS //