LOCUS       SIT99536.1               412 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            LIPID CARRIER PROTEIN OR KETO ACYL-COA THIOLASE protein.
ACCESSION   LT708304-948
PROTEIN_ID  SIT99536.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0938C"
                     /note="Mb0938c, -, len: 412 aa. Equivalent to Rv0914c,
                     len: 412 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 412 aa overlap). Possible lipid carrier
                     protein or keto acyl-CoA thiolase (EC 2.3.1.16), highly
                     similar to NP_421905.1|NC_002696 thiolase family protein
                     from Caulobacter crescentus (407 aa); and similar to
                     others e.g. NP_107896.1|NC_002678 3-ketoacyl-CoA thiolase
                     from Mesorhizobium loti (392 aa); NP_385796.1|NC_003047
                     PUTATIVE 3-KETOACYL-COA THIOLASE PROTEIN from
                     Sinorhizobium meliloti (389 aa); NP_275932.1|NC_000916
                     lipid-transfer protein (sterol or nonspecific) from
                     Methanothermobacter thermautotrophicus (383 aa);
                     AB55378.1|AL117263 possible 3-ketoacyl-CoA thiolase from
                     Leishmania major (441 aa), FASTA scores: opt: 547, E():
                     3.1e-26, (31.0% identity in 435 aa overlap); etc. Also
                     similar to Rv2790c, Rv1627c, Rv0244, etc from
                     Mycobacterium tuberculosis. COULD BELONG TO THE THIOLASE
                     FAMILY. Protein product from Mb0938c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb0938c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XWT3"
                     /db_xref="InterPro:IPR002155"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="InterPro:IPR020616"
                     /db_xref="InterPro:IPR020617"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XWT3"
BEGIN
        1 MDDGVWILGG YQSDFARNLS KENRDFADLT REVVDGTLTA AKVDAADLAA AGVVHVANAF
       61 GEMFARQGHL GAMPATVCDD LWDTPATRHE AACASGSVAT LAAMADLRSG AYRVALVVGL
      121 ELEKTVPGDT AAEHLSAAAW TGHEGAEARY LWPSMFAQVA DEYDRRYGLD DTHLRAIAQL
      181 NFANARRNPN AQTRGWTIPD PITDDDATNP LTEGRLRRFD CSQMTDGGAG LVLVSDAYLR
      241 DHRDARPIGR IDGWGHRTVG LGLRQKLDRV AQGDSAPYLL PHVRATVLDA LRRARVTLDD
      301 LDGIEVHDCF TPSEYLAIDH IGLTGPGESW KAIENGEIEI GGRLPINPSG GLIGGGHPVG
      361 ASGVRMLLDA AKQVSGIAGD YQVENAEAFG TLNFGGSTAT TVSFVVSTTR GS
//