LOCUS       SIT99525.1               236 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 TWO
            COMPONENT RESPONSE TRANSCRIPTIONAL REGULATORY PROTEIN
            PRRA protein.
ACCESSION   LT708304-937
PROTEIN_ID  SIT99525.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="prrA"
                     /locus_tag="BQ2027_MB0927C"
                     /note="Mb0927c, prrA, len: 236 aa. Equivalent to Rv0903c,
                     len: 236 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 236 aa overlap). prrA, two-component
                     response regulator (see citations below), equivalent to
                     Z99494|MLCB57_27|NP_302402.1|NC_002677 two-component
                     response regulator from Mycobacterium leprae (233 aa),
                     FASTA scores: opt: 1414, E(): 0, (95.7% identity in 233 aa
                     overlap); and similar to T45446 probable two-component
                     response regulator from Mycobacterium leprae (253 aa).
                     Also similar to many sensor-like histidine kinase proteins
                     e.g. CAB88489.1|AL353816 putative two-component systen
                     response regulator from Streptomyces coelicolor (248 aa);
                     AAG36759.1|AF119221_1 |AF119221 response regulator from
                     Corynebacterium glutamicum (232 aa); Q02540|COPR_PSESM
                     transcriptional activator protein COPR from Pseudomonas
                     syringae (pv. tomato) (227 aa), FASTA scores: opt: 600,
                     E(): 0, (44.4% identity in 225 aa overlap); etc. Also
                     similar to Rv0981 from Mycobacterium tuberculosis (230
                     aa), Rv3765c (234 aa), phoP (247 aa), etc. Thought to be
                     induced at phagocytosis (see second citation below).
                     Protein product from Mb0927c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0927c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P0A5Z7"
                     /db_xref="InterPro:IPR001789"
                     /db_xref="InterPro:IPR001867"
                     /db_xref="InterPro:IPR011006"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR039420"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5Z7"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MGGMDTGVTS PRVLVVDDDS DVLASLERGL RLSGFEVATA VDGAEALRSA TENRPDAIVL
       61 DINMPVLDGV SVVTALRAMD NDVPVCVLSA RSSVDDRVAG LEAGADDYLV KPFVLAELVA
      121 RVKALLRRRG STATSSSETI TVGPLEVDIP GRRARVNGVD VDLTKREFDL LAVLAEHKTA
      181 VLSRAQLLEL VWGYDFAADT NVVDVFIGYL RRKLEAGGGP RLLHTVRGVG FVLRMQ
//