LOCUS       SIT99524.1               446 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 TWO
            COMPONENT SENSOR HISTIDINE KINASE PRRB protein.
ACCESSION   LT708304-936
PROTEIN_ID  SIT99524.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="prrB"
                     /locus_tag="BQ2027_MB0926C"
                     /note="Mb0926c, prrB, len: 446 aa. Equivalent to Rv0902c,
                     len: 446 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100% identity in 446 aa overlap). prrB, two-component
                     sensor histidine kinase (EC 2.7.3.-) (see citations
                     below), transmembrane protein, equivalent to
                     MLCB57_26|NP_302403.1|NC_002677 sensor histidine kinase
                     from Mycobacterium leprae (446 aa); and similar at
                     C-termini to NP_301251.1|NC_002677 putative two-component
                     system sensor kinase from Mycobacterium leprae (519 aa).
                     C-terminus also similar to the C-termini of many
                     sensor-like histidine kinase proteins e.g.
                     P08336|CPXA_ECOLI|ECFB|SSD|EUP|B3911|Z5456|ECS4837 sensor
                     protein from Escherichia coli strain K12 (457 aa), FASTA
                     scores: opt: 364, E(): 1.7e-15, (27.1% identity in 398 aa
                     overlap); CAB89748.1|AL354616 putative two-component
                     histidine kinase from Streptomyces coelicolor (483 aa);
                     CAB82845.1|AJ277081 putative histidine kinase from
                     Amycolatopsis mediterranei (472 aa); etc. Also similar in
                     part to Mycobacterium tuberculosis proteins Rv3764c (475
                     aa); and Rv0982 (504 aa). Thought to be induced at
                     phagocytosis (see second citation below). Protein product
                     from Mb0926c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb0926c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A5Z9"
                     /db_xref="InterPro:IPR003594"
                     /db_xref="InterPro:IPR003660"
                     /db_xref="InterPro:IPR003661"
                     /db_xref="InterPro:IPR004358"
                     /db_xref="InterPro:IPR005467"
                     /db_xref="InterPro:IPR036097"
                     /db_xref="InterPro:IPR036890"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5Z9"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MNILSRIFAR TPSLRTRVVV ATAIGAAIPV LIVGTVVWVG ITNDRKERLD RRLDEAAGFA
       61 IPFVPRGLDE IPRSPNDQDA LITVRRGNVI KSNSDITLPK LQDDYADTYV RGVRYRVRTV
      121 EIPGPEPTSV AVGATYDATV AETNNLHRRV LLICTFAIGA AAVFAWLLAA FAVRPFKQLA
      181 EQTRSIDAGD EAPRVEVHGA SEAIEIAEAM RGMLQRIWNE QNRTKEALAS ARDFAAVSSH
      241 ELRTPLTAMR TNLEVLSTLD LPDDQRKEVL NDVIRTQSRI EATLSALERL AQGELSTSDD
      301 HVPVDITDLL DRAAHDAARI YPDLDVSLVP SPTCIIVGLP AGLRLAVDNA IANAVKHGGA
      361 TLVQLSAVSS RAGVEIAIDD NGSGVPEGER QVVFERFSRG STASHSGSGL GLALVAQQAQ
      421 LHGGTASLEN SPLGGARLVL RLPGPS
//