LOCUS       SIT99511.1               373 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CITRATE SYNTHASE II CITA protein.
ACCESSION   LT708304-923
PROTEIN_ID  SIT99511.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="citA"
                     /locus_tag="BQ2027_MB0913C"
                     /note="Mb0913c, citA, len: 373 aa. Equivalent to Rv0889c,
                     len: 373 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 373 aa overlap). Probable citA
                     (alternate gene name: gltA), citrate synthase 2 (EC
                     4.1.3.7), highly similar to others e.g.
                     CAB95899.1|AL359988 putative citrate synthase from
                     Streptomyces coelicolor (387 aa); P39119|CISY_BACSU
                     citrate synthase II from Bacillus subtilis (366 aa), FASTA
                     scores: opt: 586, E(): 5.8e-30, (33.8% identity in 367 aa
                     overlap); etc. Also similar to Rv0896|MTCY31.24 from
                     Mycobacterium tuberculosis (29.2% identity in 274 aa
                     overlap) and Rv1131. Contains PS00480 Citrate synthase
                     signature. BELONGS TO THE CITRATE SYNTHASE FAMILY. Protein
                     product from Mb0913c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0913c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P63778"
                     /db_xref="InterPro:IPR002020"
                     /db_xref="InterPro:IPR016142"
                     /db_xref="InterPro:IPR016143"
                     /db_xref="InterPro:IPR019810"
                     /db_xref="InterPro:IPR036969"
                     /db_xref="UniProtKB/Swiss-Prot:P63778"
BEGIN
        1 MTVVPENFVP GLDGVVAFTT EIAEPDKDGG ALRYRGVDIE DLVSQRVTFG DVWALLVDGN
       61 FGSGLPPAEP FPLPIHSGDV RVDVQAGLAM LAPIWGYAPL LDIDDATARQ QLARASVMAL
      121 SYVAQSARGI YQPAVPQRII DECSTVTARF MTRWQGEPDP RHIEAIDAYW VSAAEHGMNA
      181 STFTARVIAS TGADVAAALS GAIGAMSGPL HGGAPARVLP MLDEVERAGD ARSVVKGILD
      241 RGEKLMGFGH RVYRAEDPRA RVLRAAAERL GAPRYEVAVA VEQAALSELR ERRPDRAIET
      301 NVEFWAAVVL DFARVPANMM PAMFTCGRTA GWCAHILEQK RLGKLVRPSA IYVGPGPRSP
      361 ESVDGWERVL TTA
//