LOCUS SIT99486.1 142 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable molybdenum cofactor biosynthesis protein c 2 moac2 protein. ACCESSION LT708304-898 PROTEIN_ID SIT99486.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="moaC2" /locus_tag="BQ2027_MB0888" /note="Mb0888, moaC2, len: 142 aa. Similar to Rv0864, len: 167 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 142 aa overlap). Probable moaC2, molybdopterin cofactor biosynthesis protein, highly similar to others e.g. CAB59676.1|AL132674 molybdenum cofactor biosynthesis protein from Streptomyces coelicolor (170 aa); NP_418834.1|NC_002696 molybdenum cofactor biosynthesis protein C from Caulobacter crescentus (186 aa); Y10817|ANY10817_3|T44852 molybdopterin co-factor synthesis protein moaC from Arthrobacter nicotinovorans plasmid pAO1 (169 aa), FASTA scores: opt: 491, E(): 2.4e-29, (51.0% identity in 151 aa overlap); etc. Also highly similar to O05788|MOAC1|Rv3111|MTCY164.21 PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C from Mycobacterium tuberculosis (170 aa), FASTA scores: opt: 491, E(): 2.4e-29, (54.9% identity in 153 aa overlap); and O53376|Rv3324c|MOAC3|MTV016.24c PUTATIVE MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C3 (177 aa). REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) leads to a different NH2 part compared to its homolog in Mycobacterium tuberculosis strain H37Rv. Protein product from Mb0888 detected using SWATH mass spectrometry. Mb0888 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P0A5K7" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="UniProtKB/Swiss-Prot:P0A5K7" BEGIN 1 MVDITEKATT KRTAVAAGIL RTSAQVVALI STGGLPKGDA LATARVAGIM AAKRTSDLIP 61 LCHQLALTGV DVDFTVGQLD IEITATVRST DRTGVEMEAL TAVSVAALTL YDMIKAVDPG 121 ALIDDIRVLH KEGGRRGTWT RR //