LOCUS       SIT99486.1               142 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            molybdenum cofactor biosynthesis protein c 2 moac2 protein.
ACCESSION   LT708304-898
PROTEIN_ID  SIT99486.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="moaC2"
                     /locus_tag="BQ2027_MB0888"
                     /note="Mb0888, moaC2, len: 142 aa. Similar to Rv0864, len:
                     167 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 142 aa overlap). Probable moaC2,
                     molybdopterin cofactor biosynthesis protein, highly
                     similar to others e.g. CAB59676.1|AL132674 molybdenum
                     cofactor biosynthesis protein from Streptomyces coelicolor
                     (170 aa); NP_418834.1|NC_002696 molybdenum cofactor
                     biosynthesis protein C from Caulobacter crescentus (186
                     aa); Y10817|ANY10817_3|T44852 molybdopterin co-factor
                     synthesis protein moaC from Arthrobacter nicotinovorans
                     plasmid pAO1 (169 aa), FASTA scores: opt: 491, E():
                     2.4e-29, (51.0% identity in 151 aa overlap); etc. Also
                     highly similar to O05788|MOAC1|Rv3111|MTCY164.21 PUTATIVE
                     MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN C from
                     Mycobacterium tuberculosis (170 aa), FASTA scores: opt:
                     491, E(): 2.4e-29, (54.9% identity in 153 aa overlap); and
                     O53376|Rv3324c|MOAC3|MTV016.24c PUTATIVE MOLYBDENUM
                     COFACTOR BIOSYNTHESIS PROTEIN C3 (177 aa).
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a
                     frameshift due to a single base deletion (g-*) leads to a
                     different NH2 part compared to its homolog in
                     Mycobacterium tuberculosis strain H37Rv. Protein product
                     from Mb0888 detected using SWATH mass spectrometry. Mb0888
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:P0A5K7"
                     /db_xref="InterPro:IPR002820"
                     /db_xref="InterPro:IPR023045"
                     /db_xref="InterPro:IPR036522"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5K7"
BEGIN
        1 MVDITEKATT KRTAVAAGIL RTSAQVVALI STGGLPKGDA LATARVAGIM AAKRTSDLIP
       61 LCHQLALTGV DVDFTVGQLD IEITATVRST DRTGVEMEAL TAVSVAALTL YDMIKAVDPG
      121 ALIDDIRVLH KEGGRRGTWT RR
//