LOCUS       SIT99481.1               403 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            ACYL-COA THIOLASE FADA protein.
ACCESSION   LT708304-893
PROTEIN_ID  SIT99481.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fadA"
                     /locus_tag="BQ2027_MB0882"
                     /note="Mb0882, fadA, len: 403 aa. Equivalent to Rv0859,
                     len: 403 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 403 aa overlap). Possible fadA,
                     acyl-CoA thiolase (EC 2.3.1.-), equivalent to
                     NP_302423.1|NC_002677 putative beta-ketoadipyl CoA
                     thiolase from Mycobacterium leprae (403 aa). Also highly
                     similar to acyl/acetyl-CoA thiolases and beta-ketoadipyl
                     CoA thiolases, e.g. T35428 probable acetyl CoA
                     acetyltransferase (thiolase) from Streptomyces coelicolor
                     (404 aa); NP_250427.1|NC_002516 probable acyl-CoA thiolase
                     from Pseudomonas aeruginosa (401 aa);
                     NP_106253.1|NC_002678 probable acyl-CoA thiolase from
                     Mesorhizobium loti (402 aa); NP_248919.1|NC_002516|PcaF
                     beta-ketoadipyl CoA thiolase PcaF from Pseudomonas
                     aeruginosa (401 aa); etc. Contains PS00098 Thiolases
                     acyl-enzyme intermediate signature, PS00737 Thiolases
                     signature 2 and PS00099 Thiolases active site. Protein
                     product from Mb0882 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0882 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XWM6"
                     /db_xref="InterPro:IPR002155"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="InterPro:IPR020610"
                     /db_xref="InterPro:IPR020613"
                     /db_xref="InterPro:IPR020615"
                     /db_xref="InterPro:IPR020616"
                     /db_xref="InterPro:IPR020617"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XWM6"
BEGIN
        1 MSEEAFIYEA IRTPRGKQKN GSLHEVKPLS LVVGLIDELR KRHPDLDENL ISDVILGCVS
       61 PVGDQGGDIA RAAVLASGMP VTSGGVQLNR FCASGLEAVN TAAQKVRSGW DDLVLAGGVE
      121 SMSRVPMGSD GGAMGLDPAT NYDVMFVPQG IGADLIATIE GFSREDVDAY ALRSQQKAAE
      181 AWSGGYFAKS VVPVRDQNGL LILDHDEHMR PDTTKEGLAK LKPAFEGLAA LGGFDDVALQ
      241 KYHWVEKINH VHTGGNSSGI VDGAALVMIG SAAAGKLQGL TPRARIVATA TSGADPVIML
      301 TGPTPATRKV LDRAGLTVDD IDLFELNEAF ASVVLKFQKD LNIPDEKLNV NGGAIAMGHP
      361 LGATGAMILG TMVDELERRN ARRALITLCI GGGMGVATII ERV
//