LOCUS       SIT99475.1               560 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            PYRUVATE OR INDOLE-3-PYRUVATE DECARBOXYLASE PDC protein.
ACCESSION   LT708304-887
PROTEIN_ID  SIT99475.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pdc"
                     /locus_tag="BQ2027_MB0876C"
                     /note="Mb0876c, pdc, len: 560 aa. Equivalent to Rv0853c,
                     len: 560 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 560 aa overlap). Probable pdc,
                     pyruvate or indole-pyruvate decarboxylase (EC 4.1.1.-),
                     equivalent to NP_302424.1|NC_002677 pyruvate (or
                     indolepyruvate) decarboxylase from Mycobacterium leprae
                     (569 aa). Also highly similar to others e.g.
                     AAB06571.1|L80006 indolepyruvate decarboxylase from
                     Pantoea agglomerans (550 aa); Q12629|DCPY_KLULA PYRUVATE
                     DECARBOXYLASE (EC 4.1.1.1) from Kluyveromyces marxianus
                     var. lactis (563 aa); P71323 INDOLEPYRUVATE DECARBOXYLASE
                     (EC 4.1.1.74) from Enterobacter herbicola (550 aa), FASTA
                     scores: opt: 1642, E(): 0, (48.1% identity in 547 aa
                     overlap); P23234|DCIP_ENTCL INDOLE-3-PYRUVATE
                     DECARBOXYLASE (INDOLEPYRUVATE DECARBOXYLASE) from
                     Enterobacter cloacae (552 aa), FASTA scores: opt: 1596,
                     E(): 0, (46.8% identity in 551 aa overlap); etc. Contains
                     PS00187 Thiamine pyrophosphate enzymes signature and
                     PS00017 ATP/GTP-binding site motif A (P-loop). COFACTOR:
                     THIAMINE PYROPHOSPHATE. Protein product from Mb0876c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0876c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:Q7U140"
                     /db_xref="InterPro:IPR000399"
                     /db_xref="InterPro:IPR011766"
                     /db_xref="InterPro:IPR012000"
                     /db_xref="InterPro:IPR012001"
                     /db_xref="InterPro:IPR012110"
                     /db_xref="InterPro:IPR029035"
                     /db_xref="InterPro:IPR029061"
                     /db_xref="UniProtKB/Swiss-Prot:Q7U140"
BEGIN
        1 MTPQKSDACS DPVYTVGDYL LDRLAELGVS EIFGVPGDYN LQFLDHIVAH PTIRWVGSAN
       61 ELNAGYAADG YGRLRGMSAV VTTFGVGELS VTNAIAGSYA EHVPVVHIVG GPTKDAQGTR
      121 RALHHSLGDG DFEHFLRISR EITCAQANLM PATAGREIDR VLSEVREQKR PGYILLSSDV
      181 ARFPTEPPAA PLPRYPGGTS PRALSLFTKA AIELIADHQL TVLADLLVHR LQAVKELEAL
      241 LAADVVPHAT LMWGKSLLDE SSPNFLGIYA GAASAERVRA AIEGAPVLVT AGVVFTDMVS
      301 GFFSQRIDPA RTIDIGQYQS SVADQVFAPL EMSAALQALA TILTGRGISS PPVVPPPAEP
      361 PPAMPARDEP LTQQMVWDRV CSALTPGNVV LADQGTSFYG MADHRLPQGV TFIGQPLWGS
      421 IGYTLPAAVG AAVAHPDRRT VLLIGDGAAQ LTVQELGTFS REGLSPVIVV VNNDGYTVER
      481 AIHGETAPYN DIVSWNWTEL PSALGVTNHL AFRAQTYGQL DDALTVAAAR RDRMVLVEVV
      541 LPRLEIPRLL GQLVGSMAPQ
//