LOCUS       SIT99473.1               275 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            short-chain type dehydrogenase/reductase protein.
ACCESSION   LT708304-885
PROTEIN_ID  SIT99473.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0874C"
                     /note="Mb0874c, -, len: 275 aa. Equivalent to Rv0851c,
                     len: 275 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.3% identity in 275 aa overlap). Probable short-chain
                     dehydrogenase/reductase (EC 1.-.-.-), similar to many e.g.
                     Q01198|LIGD_PSEPA C ALPHA-DEHYDROGENASE (EC 1.1.1.-)(SDR
                     FAMILY) from Pseudomonas paucimobilis (Sphingomonas
                     paucimobilis) (305 aa); D11473|PSELIG_1 C
                     alpha-dehydrogenase from P. paucimobilis (305 aa), FASTA
                     scores: opt: 468, E(): 4.9e-23, (30.8% identity in 279 aa
                     overlap); NP_421969.1|NC_002696 short chain dehydrogenase
                     family protein from Caulobacter crescentus (278 aa); etc.
                     Contains PS00061 Short-chain dehydrogenases/reductases
                     family signature. BELONGS TO THE SHORT-CHAIN
                     DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Mb0874c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:A0A1R3XXK9"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR020904"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XXK9"
BEGIN
        1 MDGFPGRGAV ITGGASGIGL ATGTEFARRG ARVVLGDVDK PGLRQAVNHL RAEGFDVHGV
       61 MCDVRHREEV THLADEAFRL LGHFDVVFSN AGIVVGGPIV EMTHDDWRWV IDVDLWGSIH
      121 TVEAFLPRLL EQGTGGHVVF TASFAGLVPN AGLGAYGVAK YGVVGLAETL AREVTADGIG
      181 VSVLCPMVVE TNLVANSERI RGAACAQSST TGSPGPLPLQ DDNLGVDDIA QLTADAILAN
      241 RLYVLPHAAS RASIRRRFER IDRTFDEQAA EGWRH
//