LOCUS SIT99473.1 275 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable short-chain type dehydrogenase/reductase protein. ACCESSION LT708304-885 PROTEIN_ID SIT99473.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB0874C" /note="Mb0874c, -, len: 275 aa. Equivalent to Rv0851c, len: 275 aa, from Mycobacterium tuberculosis strain H37Rv, (99.3% identity in 275 aa overlap). Probable short-chain dehydrogenase/reductase (EC 1.-.-.-), similar to many e.g. Q01198|LIGD_PSEPA C ALPHA-DEHYDROGENASE (EC 1.1.1.-)(SDR FAMILY) from Pseudomonas paucimobilis (Sphingomonas paucimobilis) (305 aa); D11473|PSELIG_1 C alpha-dehydrogenase from P. paucimobilis (305 aa), FASTA scores: opt: 468, E(): 4.9e-23, (30.8% identity in 279 aa overlap); NP_421969.1|NC_002696 short chain dehydrogenase family protein from Caulobacter crescentus (278 aa); etc. Contains PS00061 Short-chain dehydrogenases/reductases family signature. BELONGS TO THE SHORT-CHAIN DEHYDROGENASES/REDUCTASES (SDR) FAMILY. Mb0874c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XXK9" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="UniProtKB/TrEMBL:A0A1R3XXK9" BEGIN 1 MDGFPGRGAV ITGGASGIGL ATGTEFARRG ARVVLGDVDK PGLRQAVNHL RAEGFDVHGV 61 MCDVRHREEV THLADEAFRL LGHFDVVFSN AGIVVGGPIV EMTHDDWRWV IDVDLWGSIH 121 TVEAFLPRLL EQGTGGHVVF TASFAGLVPN AGLGAYGVAK YGVVGLAETL AREVTADGIG 181 VSVLCPMVVE TNLVANSERI RGAACAQSST TGSPGPLPLQ DDNLGVDDIA QLTADAILAN 241 RLYVLPHAAS RASIRRRFER IDRTFDEQAA EGWRH //