LOCUS       SIT99445.1               389 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            TRANSCRIPTIONAL REGULATORY PROTEIN protein.
ACCESSION   LT708304-857
PROTEIN_ID  SIT99445.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0846C"
                     /note="Mb0846c, -, len: 389 aa. Equivalent to Rv0823c,
                     len: 389 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.5% identity in 389 aa overlap). Possible
                     transcriptional regulator (resembles nitrogen regulation
                     protein), equivalent (but longer 24 aa in N-terminus) to
                     MLU15182_31|U15182|NtrB NtrB protein from Mycobacterium
                     leprae (384 aa), FASTA scores: opt: 2070, E(): 0, (82.3%
                     identity in 384 aa overlap) (see citation below). Also
                     highly similar to CAB63312.1|AL133471|SCC82.03c
                     hypothetical protein from Streptomyces coelicolor (406
                     aa); and to many transcriptional regulators members of
                     UPF0034 FAMILY (NIFR3/SMM1) e.g. D26185|BAC180K_143
                     protein similar to transcriptional regulator (nitrogen
                     regulation protein) from Bacillus subtilis (333 aa), FASTA
                     scores: opt: 609, E(): 1.4e-32, (38.3% identity in 326 aa
                     overlap); NP_349795.1|NC_003030 NifR3 family enzyme from
                     Clostridium acetobutylicum (321 aa); etc. Contains PS01136
                     Uncharacterized protein family UPF0034 signature. Protein
                     product from Mb0846c detected using SWATH mass
                     spectrometry. Mb0846c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XWX6"
                     /db_xref="InterPro:IPR001269"
                     /db_xref="InterPro:IPR004652"
                     /db_xref="InterPro:IPR013785"
                     /db_xref="InterPro:IPR018517"
                     /db_xref="InterPro:IPR024036"
                     /db_xref="InterPro:IPR035587"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XWX6"
BEGIN
        1 MSRRRAIQPS PALRIGPIEL ASPVVLAPMA GVTNVAFRAL CRQLEQSKVG TVSGLYVCEM
       61 VTARALIERH PVTMHMTTFS ADESPRSLQL YTVDPDTTYA AARMIAGEGL ADHIDMNFGC
      121 PVPKVTKRGC GAALPFKRRL FGQIVAAAVR ATEGTDIPVT VKFRIGIDDA HHTHLDAGRI
      181 AEAEGAAAVA LHARTAAQRY SGTADWEQIA RLKQHVRTIP VLGNGDIYDA GDALAMMSTT
      241 GCDGVVIGRG CLGRPWLFAE LSAAFTGSPA PTPPTLGEVA DIIRRHGTLL AAHFGEDKGM
      301 RDIRKHIAWY LHGFPAGSAL RRALAMVKTL DELDCLLDRL DGTVPFPDSA TGARGRQGSP
      361 ARVALPDGWL TDPDDCRVPE GADAMGSGG
//