LOCUS       SIT99431.1               364 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE PURM (AIRS)
            (PHOSPHORIBOSYL-AMINOIMIDAZOLE SYNTHETASE) (AIR SYNTHASE)
            protein.
ACCESSION   LT708304-843
PROTEIN_ID  SIT99431.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="purM"
                     /locus_tag="BQ2027_MB0832"
                     /note="Mb0832, purM, len: 364 aa. Equivalent to Rv0809,
                     len: 364 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 364 aa overlap). Probable purM,
                     5'-phosphoribosyl-5-aminoimidazole synthetase (EC
                     6.3.3.1), equivalent to NP_302446.1|NC_002677
                     5'-phosphoribosyl-5-aminoimidazole synthase from
                     Mycobacterium leprae (364 aa). Also highly similar to many
                     e.g. P12043|PUR5_BACSU PHOSPHORIBOSYLFORMYLGLYCINAMIDINE
                     CYCLO-LIGASE from Bacillus subtilis (346 aa), FASTA
                     scores: opt: 1023, E(): 0, (46.5% identity in 331 aa
                     overlap); U68765|STU68765_2 from Salmonella typhimurium
                     (345 aa), FASTA scores: opt: 1014, E():0, (47.6% identity
                     in 330 aa overlap); etc. Protein product from Mb0832
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0832 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XWH4"
                     /db_xref="InterPro:IPR004733"
                     /db_xref="InterPro:IPR010918"
                     /db_xref="InterPro:IPR016188"
                     /db_xref="InterPro:IPR036676"
                     /db_xref="InterPro:IPR036921"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XWH4"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTDLAKGPGK DPGSRGITYA SAGVDIEAGD RAIDLFKPLA SKATRPEVRG GLGGFAGLFT
       61 LRGDYREPVL AASSDGVGTK LAIAQAMDKH DTVGLDLVAM VVDDLVVCGA EPLFLLDYIA
      121 VGRIVPERLS AIVAGIADGC MRAGCALLGG ETAEHPGLIE PDHYDISATG VGVVEADNVL
      181 GPDRVKPGDV IIAMGSSGLH SNGYSLVRKV LLEIDRMNLA GHVEEFGRTL GEELLEPTRI
      241 YAKDCLALAA ETRVRTFCHV TGGGLAGNLQ RVIPHGLIAE VDRGTWTPAP VFTMIAQRGR
      301 VRRTEMEKTF NMGVGMIAVV APEDTTRALA VLTARHLDCW VLGTVCKGGK QGPRAKLVGQ
      361 HPRF
//