LOCUS       SIT99428.1               532 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            UDP-GLUCOSE-4-EPIMERASE CPSY (GALACTOWALDENASE) (UDP-GALACTOSE-
            4-EPIMERASE) (URIDINE DIPHOSPHATE GALACTOSE-4-EPIMERASE)
            (URIDINE DIPHOSPHO-GALACTOSE-4-EPIMERASE) protein.
ACCESSION   LT708304-840
PROTEIN_ID  SIT99428.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="cpsY"
                     /locus_tag="BQ2027_MB0829C"
                     /note="Mb0829c, cpsY, len: 532 aa. Equivalent to Rv0806c,
                     len: 532 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 532 aa overlap). Possible cpsY,
                     UDP-glucose-4-epimerase (EC 5.1.3.2), equivalent to
                     Q50025|CPSY probable UDP-glucose-4-epimerase from
                     Mycobacterium leprae (542 aa), FASTA scores: opt: 2964,
                     E(): 0, (82.3% identity in 530 aa overlap). Also similar
                     to AAC38286.1|AF019760|SACB CpsY homolog (involved in
                     meningococcal capsule biosynthesis) from Neisseria
                     meningitidis serogroup A (545 aa); Q51151 CAPSULE GENE
                     COMPLEX UPD-GLUCOSE-4-EPIMERASE (GALE) from Neisseria
                     meningitidis (373 aa), FASTA scores: opt: 496, E():
                     9.5e-27, (29.3% identity in 358 aa overlap); C-terminus of
                     CAB75373.1|AL139298 putative transferase from Streptomyces
                     coelicolor (942 aa); and many hypothetical proteins from
                     Streptomyces coelicolor. SEEMS TO BELONG TO THE SUGAR
                     EPIMERASE FAMILY. Protein product from Mb0829c detected
                     using SWATH mass spectrometry. Mb0829c found to be
                     expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:Q7U184"
                     /db_xref="InterPro:IPR021520"
                     /db_xref="InterPro:IPR031356"
                     /db_xref="InterPro:IPR031357"
                     /db_xref="InterPro:IPR031358"
                     /db_xref="UniProtKB/Swiss-Prot:Q7U184"
BEGIN
        1 MPKISSRDGG RPAQRTVNPI IVTRRGKIAR LESGLTPQEA QIEDLVFLRK VLNRADIPYL
       61 LIRNHKNRPV LAINIELRAG LERALAAACA TEPMYAKTID EPGLSPVLVA TDGLSQLVDP
      121 RVVRLYRRRI APGGFRYGPA FGVELQFWVY EETVIRCPVE NSLSRKVLPR NEITPTNVKL
      181 YGYKWPTLDG MFAPHASDVV FDIDMVFSWV DGSDPEFRAR RMAQMSQYVV GEGDDAEARI
      241 RQIDELKYAL RSVNMFAPWI RRIFIATDST PPPWLAEHPK ITIVRAEDHF SDRSALPTYN
      301 SHAVESQLHH IPGLSEHFLY SNDDMFFGRP LKASMFFSPG GVTRFIEAKT RIGLGANNPA
      361 RSGFENAARV NRQLLFDRFG QVITRHLEHT AVPLRKSVLI EMEREFPEEF ARTAASPFRS
      421 DTDISVTNSF YHYYALMTGR AVPQEKAKVL YVDTTSYAGL RLLPKLRKHR GYDFFCLNDG
      481 SFPEVPAAQR AERVVSFLER YFPIPAPWEK IAADVSRRDF AVPRTSAPSE GA
//