LOCUS       SIT99425.1               754 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PHOSPHORIBOSYLFOR
            MYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II) protein.
ACCESSION   LT708304-837
PROTEIN_ID  SIT99425.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="purL"
                     /locus_tag="BQ2027_MB0826"
                     /note="Mb0826, purL, len: 754 aa. Equivalent to Rv0803,
                     len: 754 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 754 aa overlap). purL,
                     phosphoribosylformylglycinamidine synthase II (EC 6.3.5.3)
                     (see citations below), equivalent to NP_302451.1|NC_002677
                     phosphoribosylformylglycinamidine synthase II from
                     Mycobacterium leprae (754 aa). Also highly similar to
                     others e.g. Q9RKK5|PURL_STRCO from Streptomyces coelicolor
                     (752 aa); P12042|PURL_BACSU from Bacillus subtilis (742
                     aa), FASTA score: (44.7% identity in 716 aa); etc. Start
                     was chosen by similarity. BELONGS TO THE FGAMS FAMILY.
                     Protein product from Mb0826 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0826 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P0A5T9"
                     /db_xref="InterPro:IPR010074"
                     /db_xref="InterPro:IPR010918"
                     /db_xref="InterPro:IPR016188"
                     /db_xref="InterPro:IPR036676"
                     /db_xref="InterPro:IPR036921"
                     /db_xref="InterPro:IPR041609"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5T9"
BEGIN
        1 MLDTVEHAAT TPDQPQPYGE LGLKDDEYRR IRQILGRRPT DTELAMYSVM WSEHCSYKSS
       61 KVHLRYFGET TSDEMRAAML AGIGENAGVV DIGDGWAVTF KVESHNHPSY VEPYQGAATG
      121 VGGIVRDIMA MGARPVAVMD QLRFGAADAP DTRRVLDGVV RGIGGYGNSL GLPNIGGETV
      181 FDPCYAGNPL VNALCVGVLR QEDLHLAFAS GAGNKIILFG ARTGLDGIGG VSVLASDTFD
      241 AEGSRKKLPS VQVGDPFMEK VLIECCLELY AGGLVIGIQD LGGAGLSCAT SELASAGDGG
      301 MTIQLDSVPL RAKEMTPAEV LCSESQERMC AVVSPKNVDA FLAVCRKWEV LATVIGEVTD
      361 GDRLQITWHG ETVVDVPPRT VAHEGPVYQR PVARPDTQDA LNADRSAKLS RPVTGDELRA
      421 TLLALLGSPH LCSRAFITEQ YDRYVRGNTV LAEHADGGML RIDESTGRGI AVSTDASGRY
      481 TLLDPYAGAQ LALAEAYRNV AVTGATPVAV TNCLNFGSPE DPGVMWQFTQ AVRGLADGCA
      541 DLGIPVTGGN VSFYNQTGSA AILPTPVVGV LGVIDDVRRR IPTGLGAEPG ETLMLLGDTR
      601 DEFDGSVWAQ VTADHLGGLP PVVDLAREKL LAAVLSSASR DGLVSAAHDL SEGGLAQAIV
      661 ESALAGETGC RIVLPEGADP FVLLFSESAG RVLVAVPRTE ESRFRGMCEA RGLPAVRIGV
      721 VDQGSDAVEV QGLFAVSLAE LRATSEAVLP RYFG
//