LOCUS SIT99425.1 754 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PHOSPHORIBOSYLFOR MYLGLYCINAMIDINE SYNTHASE II PURL (FGAM SYNTHASE II) protein. ACCESSION LT708304-837 PROTEIN_ID SIT99425.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="purL" /locus_tag="BQ2027_MB0826" /note="Mb0826, purL, len: 754 aa. Equivalent to Rv0803, len: 754 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 754 aa overlap). purL, phosphoribosylformylglycinamidine synthase II (EC 6.3.5.3) (see citations below), equivalent to NP_302451.1|NC_002677 phosphoribosylformylglycinamidine synthase II from Mycobacterium leprae (754 aa). Also highly similar to others e.g. Q9RKK5|PURL_STRCO from Streptomyces coelicolor (752 aa); P12042|PURL_BACSU from Bacillus subtilis (742 aa), FASTA score: (44.7% identity in 716 aa); etc. Start was chosen by similarity. BELONGS TO THE FGAMS FAMILY. Protein product from Mb0826 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb0826 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:P0A5T9" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="InterPro:IPR041609" /db_xref="UniProtKB/Swiss-Prot:P0A5T9" BEGIN 1 MLDTVEHAAT TPDQPQPYGE LGLKDDEYRR IRQILGRRPT DTELAMYSVM WSEHCSYKSS 61 KVHLRYFGET TSDEMRAAML AGIGENAGVV DIGDGWAVTF KVESHNHPSY VEPYQGAATG 121 VGGIVRDIMA MGARPVAVMD QLRFGAADAP DTRRVLDGVV RGIGGYGNSL GLPNIGGETV 181 FDPCYAGNPL VNALCVGVLR QEDLHLAFAS GAGNKIILFG ARTGLDGIGG VSVLASDTFD 241 AEGSRKKLPS VQVGDPFMEK VLIECCLELY AGGLVIGIQD LGGAGLSCAT SELASAGDGG 301 MTIQLDSVPL RAKEMTPAEV LCSESQERMC AVVSPKNVDA FLAVCRKWEV LATVIGEVTD 361 GDRLQITWHG ETVVDVPPRT VAHEGPVYQR PVARPDTQDA LNADRSAKLS RPVTGDELRA 421 TLLALLGSPH LCSRAFITEQ YDRYVRGNTV LAEHADGGML RIDESTGRGI AVSTDASGRY 481 TLLDPYAGAQ LALAEAYRNV AVTGATPVAV TNCLNFGSPE DPGVMWQFTQ AVRGLADGCA 541 DLGIPVTGGN VSFYNQTGSA AILPTPVVGV LGVIDDVRRR IPTGLGAEPG ETLMLLGDTR 601 DEFDGSVWAQ VTADHLGGLP PVVDLAREKL LAAVLSSASR DGLVSAAHDL SEGGLAQAIV 661 ESALAGETGC RIVLPEGADP FVLLFSESAG RVLVAVPRTE ESRFRGMCEA RGLPAVRIGV 721 VDQGSDAVEV QGLFAVSLAE LRATSEAVLP RYFG //