LOCUS       SIT99422.1               433 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            AMINOPEPTIDASE PEPC protein.
ACCESSION   LT708304-834
PROTEIN_ID  SIT99422.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pepC"
                     /locus_tag="BQ2027_MB0823"
                     /note="Mb0823, pepC, len: 433 aa. Equivalent to Rv0800,
                     len: 433 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 433 aa overlap). Probable pepC,
                     aminopeptidase I (EC 3.4.11.-), highly similar (but
                     shorter 17 aa) to Q50022|PEPX AMINOPEPTIDASE from
                     Mycobacterium leprae (443 aa), FASTA scores: opt: 2237,
                     E(): 0, (78.3% identity in 433 aa overlap). Also highly
                     similar to others from Eukaryotes and bacteria, e.g.
                     T36482 probable aminopeptidase from Streptomyces
                     coelicolor (432 aa), P14904|AMPL_YEAST vacuolar
                     aminopeptidase I precursor from Saccharomyces cerevisiae
                     (514 aa), FASTA scores: opt: 425, E(): 4.8e-21, (31.0%
                     identity in 445 aa overlap); etc. Also similar to
                     hypothetical proteins e.g. P38821|YHR3_YEAST hypothetical
                     54.2 kd protein from Saccharomyces cerevisiae (490 aa),
                     FASTA scores: opt: 429, E(): 2.5e-21, (34.8% identity in
                     443 aa overlap); etc. Protein product from Mb0823 detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0823 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P59951"
                     /db_xref="InterPro:IPR001948"
                     /db_xref="InterPro:IPR022984"
                     /db_xref="InterPro:IPR023358"
                     /db_xref="UniProtKB/Swiss-Prot:P59951"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MAATAHGLCE FIDASPSPFH VCATVAGRLL GAGYRELREA DRWPDKPGRY FTVRAGSLVA
       61 WNAEQSGHTQ VPFRIVGAHT DSPNLRVKQH PDRLVAGWHV VALQPYGGVW LHSWLDRDLG
      121 ISGRLSVRDG TGVSHRLVRI DDPILRVPQL AIHLAEDRKS LTLDPQRHIN AVWGVGERVE
      181 SFVGYVAQRA GVAAADVLAA DLMTHDLTPS ALIGASVNGT ASLLSAPRLD NQASCYAGME
      241 ALLAVDVDSA SSGFVPVLAI FDHEEVGSAS GHGAQSDLLS SVLERIVLAA GGTREDFLRR
      301 LTTSMLASAD MAHATHPNYP DRHEPSHPIE VNAGPVLKVH PNLRYATDGR TAAAFALACQ
      361 RAGVPMQRYE HRADLPCGST IGPLAAARTG IPTVDVGAAQ LAMHSARELM GAHDVAAYSA
      421 ALQAFLSAEL SEA
//