LOCUS SIT99418.1 299 aa PRT BCT 25-MAY-2020
DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
OXIDOREDUCTASE [FIRST PART] protein.
ACCESSION LT708304-830
PROTEIN_ID SIT99418.1
SOURCE Mycobacterium tuberculosis variant bovis AF2122/97
ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE 1
AUTHORS Malone K.M.
JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine, University College
Dublin, D4, Ireland
REFERENCE 2
AUTHORS Malone M K., Farrell D., Malone K.
JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary
Medicine, Tuberculosis Molecular Microbiology Research Group,
University College Dublin, Tuberculosis Molecular Microbiology
Research Group, School of Veterinary Medicine,, University College
Dublin, D4, Ireland
FEATURES Qualifiers
source /organism="Mycobacterium tuberculosis variant bovis
AF2122/97"
/chromosome="Mycobacterium_bovis_AF212297"
/isolate="AF2122/97"
/mol_type="genomic DNA"
/isolation_source="Mycobacterium bovis subsp. bovis strain
AF2122/97. This strain is a fully virulent strain that was
isolated in 1997 in the UK from a cow suffering necrotic
lesions in lung and bronchomediastinal lymph nodes. The
strain was also reported to infect and persist in badgers
that are considered to be a significant source of bovine
infection."
/db_xref="taxon:233413"
protein /transl_table=11
/locus_tag="BQ2027_MB0819C"
/note="Mb0819c, -, len: 299 aa. Equivalent to 5' end of
Rv0794c, len: 499 aa, from Mycobacterium tuberculosis
strain H37Rv, (100.0% identity in 263 aa overlap).
Probable oxidoreductase (EC 1.-.-.-), possibly
dihydrolipoamide dehydrogenase (EC 1.8.1.4) or mercuric
reductase (EC 1.16.1.1). Highly similar to
CAB62675.1|AL133422 probable oxidoreductase from
Streptomyces coelicolor (477 aa); and similar to various
oxidoreductases e.g. P08663|MERA_STAAU MERCURIC REDUCTASE
(HG(II) REDUCTASE) (EC 1.16.1.1) from Staphylococcus
aureus (547 aa); AAK70920.1|AC087551_19|AC087551 putative
lipoamide dehydrogenase from Oryza sativa (563 aa);
NP_437349.1|NC_003078 putative FAD-dependent pyridine
nucleotide-disulphide oxidoreductase, similar to mercuric
reductases protein from Sinorhizobium meliloti (473 aa);
Q04829|DLDH_HALVO DIHYDROLIPOAMIDE DEHYDROGENASE (EC
1.8.1.4) from Haloferax volcanii (475 aa);
P08332|MERA_SHIFL MERCURIC REDUCTASE (EC 1.16.1.1) (564
aa), FASTA scores: opt: 522, E(): 3.7e-26, (31.7% identity
in 467 aa overlap);
P72740|DLDH_SYNY3|Q53395|LPDA|PDHD|SLR1096
DIHYDROLIPOAMIDE DEHYDROGENASE (EC 1.8.1.4) from
Synechocystis sp. strain PCC 6803 (474 aa), FASTA scores:
opt: 602, E(): 2.3e-31, (31.0% identity in 493 aa
overlap); etc. Note that previously known as lpdB.
REMARK-M.bovis-M.tuberculosis: In Mycobacterium
tuberculosis strain H37Rv, Rv0794c exists as a single
gene. In Mycobacterium bovis, a frameshift due to a single
base deletion (a-*) splits Mb0818c into 2 parts, Mb0818a
and Mb0818b. Mb0819c found to be expressed during
exponential growth in Sauton's minimal media by
RNA-sequencing."
/db_xref="GOA:A0A1R3XWG0"
/db_xref="InterPro:IPR023753"
/db_xref="InterPro:IPR036188"
/db_xref="UniProtKB/TrEMBL:A0A1R3XWG0"
BEGIN
1 MTAAQQDQAP MATPGCREGE TYDVVVLGAG PVGQNVADRA RAGGLRVAVV ERELVGGECS
61 YWACVPSKAL LRPVIAISDA RRVDGAREAV DGSINTAGVF GRRNRYVAHW DDTGQADWVS
121 GIGATLIRGD GRLDGPRRVV VTKSSGESVA LTARHAVVIC TGSRPALPDL PGITEARPWT
181 NRQATDNSTV PDRLAIVGAG GVGVEMATAW QGLGASVTLL ARGSGLLPRM EPFVGELIGR
241 GLADAGVDVR VGVSVRALGR PNPLAQWSSS WTTVPSCGST RYSSPPAEHR EPTTSAWRQ
//