LOCUS       SIT99406.1               191 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 CONSERVED
            HYPOTHETICAL PROTEIN [FIRST PART] protein.
ACCESSION   LT708304-818
PROTEIN_ID  SIT99406.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0807"
                     /note="Mb0807, -, len: 191 aa. Equivalent to 5' end of
                     Rv0785, len: 566 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (97.1% identity in 140 aa overlap).
                     Conserved hypothetical protein, highly similar to other
                     conserved hypothetical proteins e.g. NP_105777.1|
                     NC_002678 hypothetical protein from Mesorhizobium loti
                     (552 aa); SC5F8.14|CAB93742.1|AL357613 conserved
                     hypothetical protein from Streptomyces coelicolor (557
                     aa); AE001863|AE001863_31 from Deinococcus radiodurans
                     (554 aa), FASTA scores: opt: 2243, E(): 0, (61.1% identity
                     in 550 aa overlap); YEF7_YEAST|P32614 hypothetical 50.8 kd
                     protein (470 aa), FASTA scores: opt: 169, E(): 0.0014,
                     (23.8% identity in 542 aa overlap); etc. Also similar to
                     Rv1817|MTCY1A11.26c from Mycobacterium tuberculosis (487
                     aa), FASTA score: (26.7% identity in 587 aa overlap). And
                     shows similarity with other dehydrogenases.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, Rv0785 exists as a single gene.
                     In Mycobacterium bovis, a frameshift due to a single base
                     deletion (t-*), splits Mb0807 into 2 parts, Mb0807 and
                     Mb0808. Mb0807 found to be expressed during exponential
                     growth in Sauton's minimal media by RNA-sequencing (TPM >
                     20)."
                     /db_xref="GOA:A0A1R3XWF0"
                     /db_xref="InterPro:IPR003953"
                     /db_xref="InterPro:IPR014614"
                     /db_xref="InterPro:IPR036188"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XWF0"
BEGIN
        1 MALTCTDMSD AVAGSDAEGL TADAIVVGAG LAGLVAACEL ADRGLRVLIL DQENRANVGG
       61 QAFWSFGGLF LVNSPEQRRL GIRDSHELAL QDWLGTAAFD RPEDYWPEQW AHAYVDFAAG
      121 EKRSWLRARG LKIFRWWAGP SVVVTTRRGT ATRCPVSTSP GVLGRLWSTY SCVSCVIAPR
      181 CALRTATRST N
//