LOCUS SIT99406.1 191 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 CONSERVED HYPOTHETICAL PROTEIN [FIRST PART] protein. ACCESSION LT708304-818 PROTEIN_ID SIT99406.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB0807" /note="Mb0807, -, len: 191 aa. Equivalent to 5' end of Rv0785, len: 566 aa, from Mycobacterium tuberculosis strain H37Rv, (97.1% identity in 140 aa overlap). Conserved hypothetical protein, highly similar to other conserved hypothetical proteins e.g. NP_105777.1| NC_002678 hypothetical protein from Mesorhizobium loti (552 aa); SC5F8.14|CAB93742.1|AL357613 conserved hypothetical protein from Streptomyces coelicolor (557 aa); AE001863|AE001863_31 from Deinococcus radiodurans (554 aa), FASTA scores: opt: 2243, E(): 0, (61.1% identity in 550 aa overlap); YEF7_YEAST|P32614 hypothetical 50.8 kd protein (470 aa), FASTA scores: opt: 169, E(): 0.0014, (23.8% identity in 542 aa overlap); etc. Also similar to Rv1817|MTCY1A11.26c from Mycobacterium tuberculosis (487 aa), FASTA score: (26.7% identity in 587 aa overlap). And shows similarity with other dehydrogenases. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, Rv0785 exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (t-*), splits Mb0807 into 2 parts, Mb0807 and Mb0808. Mb0807 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3XWF0" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR014614" /db_xref="InterPro:IPR036188" /db_xref="UniProtKB/TrEMBL:A0A1R3XWF0" BEGIN 1 MALTCTDMSD AVAGSDAEGL TADAIVVGAG LAGLVAACEL ADRGLRVLIL DQENRANVGG 61 QAFWSFGGLF LVNSPEQRRL GIRDSHELAL QDWLGTAAFD RPEDYWPEQW AHAYVDFAAG 121 EKRSWLRARG LKIFRWWAGP SVVVTTRRGT ATRCPVSTSP GVLGRLWSTY SCVSCVIAPR 181 CALRTATRST N //