LOCUS       SIT99400.1               414 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            CYTOCHROME P450 126 CYP126 protein.
ACCESSION   LT708304-812
PROTEIN_ID  SIT99400.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="cyp126"
                     /locus_tag="BQ2027_MB0801"
                     /note="Mb0801, cyp126, len: 414 aa. Equivalent to Rv0778,
                     len: 414 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 414 aa overlap). Possible cyp126,
                     cytochrome P-450 (EC 1.14.-.-), similar to other
                     cytochromes and related proteins e.g.
                     AAG29781.1|AF235050_4|AF235050 cytochrome P-450 from
                     Streptomyces rishiriensis (407 aa); Q59723|PSECYTOCHR_1
                     cytochrome p-450 linalool 8-monooxygenase (EC 1.14.99.28)
                     (lin C) from Pseudomonas incognita (406 aa), FASTA scores:
                     opt: 769, E(): 0, (37.0% identity in 411 aa overlap); etc.
                     Also similar to others from Mycobacterium tuberculosis
                     e.g. Rv0766c, Rv2266, Rv3545c, etc. Contains PS00086
                     Cytochrome P450 cysteine heme-iron ligand signature.
                     Protein product from Mb0801 detected using SWATH mass
                     spectrometry. Mb0801 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P63712"
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002397"
                     /db_xref="InterPro:IPR017972"
                     /db_xref="InterPro:IPR036396"
                     /db_xref="UniProtKB/Swiss-Prot:P63712"
BEGIN
        1 MTTAAGLSGI DLTDLDNFAD GFPHHLFAIH RREAPVYWHR PTEHTPDGEG FWSVATYAET
       61 LEVLRDPVTY SSVTGGQRRF GGTVLQDLPV AGQVLNMMDD PRHTRIRRLV SSGLTPRMIR
      121 RVEDDLRRRA RGLLDGVEPG APFDFVVEIA AELPMQMICI LLGVPETDRH WLFEAVEPGF
      181 DFRGSRRATM PRLNVEDAGS RLYTYALELI AGKRAEPADD MLSVVANATI DDPDAPALSD
      241 AELYLFFHLL FSAGAETTRN SIAGGLLALA ENPDQLQTLR SDFELLPTAI EEIVRWTSPS
      301 PSKRRTASRA VSLGGQPIEA GQKVVVWEGS ANRDPSVFDR ADEFDITRKP NPHLGFGQGV
      361 HYCLGANLAR LELRVLFEEL LSRFGSVRVV EPAEWTRSNR HTGIRHLVVE LRGG
//