LOCUS SIT99400.1 414 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE CYTOCHROME P450 126 CYP126 protein. ACCESSION LT708304-812 PROTEIN_ID SIT99400.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="cyp126" /locus_tag="BQ2027_MB0801" /note="Mb0801, cyp126, len: 414 aa. Equivalent to Rv0778, len: 414 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 414 aa overlap). Possible cyp126, cytochrome P-450 (EC 1.14.-.-), similar to other cytochromes and related proteins e.g. AAG29781.1|AF235050_4|AF235050 cytochrome P-450 from Streptomyces rishiriensis (407 aa); Q59723|PSECYTOCHR_1 cytochrome p-450 linalool 8-monooxygenase (EC 1.14.99.28) (lin C) from Pseudomonas incognita (406 aa), FASTA scores: opt: 769, E(): 0, (37.0% identity in 411 aa overlap); etc. Also similar to others from Mycobacterium tuberculosis e.g. Rv0766c, Rv2266, Rv3545c, etc. Contains PS00086 Cytochrome P450 cysteine heme-iron ligand signature. Protein product from Mb0801 detected using SWATH mass spectrometry. Mb0801 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P63712" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="UniProtKB/Swiss-Prot:P63712" BEGIN 1 MTTAAGLSGI DLTDLDNFAD GFPHHLFAIH RREAPVYWHR PTEHTPDGEG FWSVATYAET 61 LEVLRDPVTY SSVTGGQRRF GGTVLQDLPV AGQVLNMMDD PRHTRIRRLV SSGLTPRMIR 121 RVEDDLRRRA RGLLDGVEPG APFDFVVEIA AELPMQMICI LLGVPETDRH WLFEAVEPGF 181 DFRGSRRATM PRLNVEDAGS RLYTYALELI AGKRAEPADD MLSVVANATI DDPDAPALSD 241 AELYLFFHLL FSAGAETTRN SIAGGLLALA ENPDQLQTLR SDFELLPTAI EEIVRWTSPS 301 PSKRRTASRA VSLGGQPIEA GQKVVVWEGS ANRDPSVFDR ADEFDITRKP NPHLGFGQGV 361 HYCLGANLAR LELRVLFEEL LSRFGSVRVV EPAEWTRSNR HTGIRHLVVE LRGG //