LOCUS       SIT99394.1               422 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE
            RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE
            SYNTHETASE) (5'-PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE)
            protein.
ACCESSION   LT708304-806
PROTEIN_ID  SIT99394.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="purD"
                     /locus_tag="BQ2027_MB0795"
                     /note="Mb0795, purD, len: 422 aa. Equivalent to Rv0772,
                     len: 422 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 422 aa overlap). Probable purD,
                     phosphoribosylamine--glycine ligase (EC 6.3.4.13),
                     equivalent to Q50144|PURD|PUR2_MYCLE|ML2235|MLCB5.08
                     PHOSPHORIBOSYLAMINE--GLYCINE LIGASE from Mycobacterium
                     leprae (422 aa), FASTA scores: opt: 2272, E(): 0, (81.8%
                     identity in 422 aa overlap). Also highly similar to others
                     e.g. CAB56348.1|AL118514 phosphoribosylamine-glycine
                     ligase from Streptomyces coelicolor (416 aa);
                     P1564|PUR2_ECOLI phosphoribosylamine--glycine ligase from
                     Escherichia coli (429 aa), FASTA scores: opt: 1039, E():
                     0, (42.7% identity in 431 aa overlap); etc. BELONGS TO THE
                     GARS FAMILY. Protein product from Mb0795 detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb0795 found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:P65894"
                     /db_xref="InterPro:IPR000115"
                     /db_xref="InterPro:IPR011054"
                     /db_xref="InterPro:IPR011761"
                     /db_xref="InterPro:IPR013815"
                     /db_xref="InterPro:IPR016185"
                     /db_xref="InterPro:IPR020559"
                     /db_xref="InterPro:IPR020560"
                     /db_xref="InterPro:IPR020561"
                     /db_xref="InterPro:IPR020562"
                     /db_xref="InterPro:IPR037123"
                     /db_xref="UniProtKB/Swiss-Prot:P65894"
BEGIN
        1 MRVLVIGSGA REHALLLALG KDPQVSGLIV APGNAGTARI AEQHDVDITS AEAVVALARE
       61 VGADMVVIGP EVPLVLGVAD AVRAAGIVCF GPGKDAARIE GSKAFAKDVM AAAGVRTANS
      121 EIVDSPAHLD AALDRFGPPA GDPAWVVKDD RLAAGKGVVV TADRDVARAH GAALLEAGHP
      181 VLLESYLDGP EVSLFCVVDR TVVVPLLPAQ DFKRVGEDDT GLNTGGMGAY APLPWLPDNI
      241 YREVVSRIVE PVAAELVRRG SSFCGLLYVG LAITARGPAV VEFNCRFGDP ETQAVLALLE
      301 SPLGQLLHAA ATGKLADFGE LRWRDGVAVT VVLAAENYPG RPRVGDVVVG SEAEGVLHAG
      361 TTRRDDGAIV SSGGRVLSVV GTGADLSAAR AHAYEILSSI RLPGGHFRSD IGLRAAEGKI
      421 SV
//