LOCUS       SIT99393.1               144 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            4-CARBOXYMUCONOLACTONE DECARBOXYLASE (CMD) protein.
ACCESSION   LT708304-805
PROTEIN_ID  SIT99393.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0794"
                     /note="Mb0794, -, len: 144 aa. Equivalent to Rv0771, len:
                     144 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 144 aa overlap). Possible
                     4-carboxymuconolactone decarboxylase (EC 4.1.1.44),
                     showing similarity with other carboxymuconolactone
                     decarboxylases e.g. AAD39557.1|AF031417 PcaC-like protein
                     from Pseudomonas putida (130 aa); P20370|DC4C_ACICA
                     4-CARBOXYMUCONOLACTONE DECARBOXYLASE (CMD) from
                     Acinetobacter sp. ADP1 (134 aa), FASTA scores: opt: 174,
                     E(): 0.00075, (31.4% identity in 121 aa overlap);
                     C-terminus of NP_421214.1|NC_002696 3-oxoadipate
                     enol-lactone hydrolase/4-carboxymuconolactone
                     decarboxylase from Caulobacter crescentus (393 aa);
                     C-terminus of T47115 probable 4-carboxymuconolactone
                     decarboxylase / 3-oxoadipate enol-lactone hydrolase from
                     Streptomyces sp (373 aa); NP_407104.1|NC_003143 putative
                     gamma carboxymuconolactone decarboxylase from Yersinia
                     pestis (131 aa); etc. Protein product from Mb0794 detected
                     using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0794 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XXC9"
                     /db_xref="InterPro:IPR003779"
                     /db_xref="InterPro:IPR029032"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XXC9"
BEGIN
        1 MMDELRRTGL DKMNEVYAWD MPDMPGEFFA LTVDHLFGRI WTRPGLSMRD RRMAVIAVLT
       61 AQGQSDLLEV QVNAVLHNDE LTIDELRELA VFITHYVGFP LGSRLNSAIE RVAAKRKQAA
      121 ENGSLPDTKA NVAEVLAKES GKSS
//