LOCUS       SIT99392.1               295 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            DEHYDROGENASE/REDUCTASE protein.
ACCESSION   LT708304-804
PROTEIN_ID  SIT99392.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0793"
                     /note="Mb0793, -, len: 295 aa. Equivalent to Rv0770, len:
                     295 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 295 aa overlap). Probable
                     dehydrogenase/reductase, 3-hydroxyisobutyrate
                     dehydrogenase family (EC 1.1.1.-), possibly
                     3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) or
                     2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60), similar
                     to others e.g. P23523|GARR_ECOLI 2-HYDROXY-3-OXOPROPIONATE
                     REDUCTASE (TARTRONATE SEMIALDEHYDE REDUCTASE) (TSAR) from
                     Escherichia coli strain K12 (294 aa), FASTA scores: opt:
                     469, E(): 6.7e-22, (34.4% identity in 282 aa overlap);
                     P28811|MMSB_PSEAE 3-hydroxyisobutyrate dehydrogenase
                     (HIBADH) from Pseudomonas aeruginosa (298 aa), FASTA
                     scores: opt: 439, E(): 4.3e-20, (34.9% identity in 269 aa
                     overlap); etc. Also similar to others from Mycobacterium
                     tuberculosis e.g. Rv1122 and Rv1844c. SEEMS TO BELONG TO
                     THE 3-HYDROXYISOBUTYRATE DEHYDROGENASE FAMILY. Mb0793
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3XYH6"
                     /db_xref="InterPro:IPR002204"
                     /db_xref="InterPro:IPR006115"
                     /db_xref="InterPro:IPR008927"
                     /db_xref="InterPro:IPR013328"
                     /db_xref="InterPro:IPR015815"
                     /db_xref="InterPro:IPR029154"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XYH6"
BEGIN
        1 MTAHPETPRL GYIGLGNQGA PMAKRLLDWP GGLTVFDVRV EAMAPFVEGG ATAAASVSDV
       61 AEADIISITV FDDAQVSSVI TADNGLATHA KPGTIVAIHS TIADTTAVDL AEKLKPQGIH
      121 IVDAPGSGGA AAAAKGELAV MVGADDEAFQ RIKEPFSRWA SLLIHAGEPG AGTRMKLARN
      181 MLTFVSYAAA AEAQRLAEAC GLDLVALGKV VRHSDSFTGG AGAIMFRNTT APMEPADPLR
      241 PLLEHTRGLG EKDLSLALAL GEVVSVDLPL AQLALQRLAA GLGVPHPDTE PAKET
//