LOCUS SIT99390.1 489 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 probable aldehyde dehydrogenase nad dependent alda (aldehyde dehydrogenase [nad+]) protein. ACCESSION LT708304-802 PROTEIN_ID SIT99390.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="aldA" /locus_tag="BQ2027_MB0791" /note="Mb0791, aldA, len: 489 aa. Equivalent to Rv0768, len: 489 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 489 aa overlap). Probable aldA, NAD-dependent aldehyde dehydrogenase (EC 1.2.1.-), highly similar to others e.g. AAL14238.1|AY052630 6-oxolauric acid dehydrogenase from Rhodococcus ruber (474 aa); NP_285450.1|NC_001264 aldehyde dehydrogenase from Deinococcus radiodurans (495 aa); NP_241405.1|NC_002570 NADP-dependent aldehyde dehydrogenase from Bacillus halodurans (498 aa); P42757|DHAB_ATRHO betaine-aldehyde dehydrogenase precursor from Atriplex hortensis (Mountain spinach) (502 aa), FASTA scores: opt: 1001, E(): 0, (35.6% identity in 486 aa overlap); etc. Also highly similar to Rv0223c ALDEHYDE DEHYDROGENASE from Mycobacterium tuberculosis (487 aa). Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. BELONGS TO THE ALDEHYDE DEHYDROGENASES FAMILY. Protein product from Mb0791 detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb0791 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XWD8" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR016163" /db_xref="InterPro:IPR026460" /db_xref="InterPro:IPR029510" /db_xref="UniProtKB/TrEMBL:A0A1R3XWD8" BEGIN 1 MALWGDGISA LLIDGKLSDG RAGTFPTVNP ATEEVLGVAA DADAEDMGRA IEAARRAFDS 61 TDWSRNTELR VRCVRQLRDA MQQHVEELRE LTISEVGAPR MLTASAQLEG PVGDLSFAAD 121 TAESYPWKQD LGEASPLGIA TRRTLAREAV GVVGAITPWN FPHQINLAKL GPALAAGNTV 181 VLKPAPDTPW CAAALGEIIV EHTDFPPGVV NIVTSSSHAL GALLAKDPRV DMISFTGSTA 241 TGRAVMADAA ATIKKVFLEL GGKSAFVVLD DADLAAASAV SAFSACMHAG QGCAITTRLV 301 VPRARYEEAV AIAAATMSSI RPGDPNDPGT VCGPLISARQ RDRVQGYLDL AVAEGGRFAC 361 GGARPADREV GFYIEPTVIA GLTNDARVAR EEIFGPVLTV IAHDGDDDAV RIANDSPYGL 421 SGTVYGADPQ RAARIASRLR VGTVNVNGGV WYCADAPFGG YKQSGIGREM GLLGFEEYLE 481 AKLIATAAN //