LOCUS       SIT99390.1               489 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            aldehyde dehydrogenase nad dependent alda (aldehyde dehydrogenase
            [nad+]) protein.
ACCESSION   LT708304-802
PROTEIN_ID  SIT99390.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="aldA"
                     /locus_tag="BQ2027_MB0791"
                     /note="Mb0791, aldA, len: 489 aa. Equivalent to Rv0768,
                     len: 489 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 489 aa overlap). Probable aldA,
                     NAD-dependent aldehyde dehydrogenase (EC 1.2.1.-), highly
                     similar to others e.g. AAL14238.1|AY052630 6-oxolauric
                     acid dehydrogenase from Rhodococcus ruber (474 aa);
                     NP_285450.1|NC_001264 aldehyde dehydrogenase from
                     Deinococcus radiodurans (495 aa); NP_241405.1|NC_002570
                     NADP-dependent aldehyde dehydrogenase from Bacillus
                     halodurans (498 aa); P42757|DHAB_ATRHO betaine-aldehyde
                     dehydrogenase precursor from Atriplex hortensis (Mountain
                     spinach) (502 aa), FASTA scores: opt: 1001, E(): 0, (35.6%
                     identity in 486 aa overlap); etc. Also highly similar to
                     Rv0223c ALDEHYDE DEHYDROGENASE from Mycobacterium
                     tuberculosis (487 aa). Contains PS00687 Aldehyde
                     dehydrogenases glutamic acid active site. BELONGS TO THE
                     ALDEHYDE DEHYDROGENASES FAMILY. Protein product from
                     Mb0791 detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb0791 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XWD8"
                     /db_xref="InterPro:IPR015590"
                     /db_xref="InterPro:IPR016161"
                     /db_xref="InterPro:IPR016162"
                     /db_xref="InterPro:IPR016163"
                     /db_xref="InterPro:IPR026460"
                     /db_xref="InterPro:IPR029510"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XWD8"
BEGIN
        1 MALWGDGISA LLIDGKLSDG RAGTFPTVNP ATEEVLGVAA DADAEDMGRA IEAARRAFDS
       61 TDWSRNTELR VRCVRQLRDA MQQHVEELRE LTISEVGAPR MLTASAQLEG PVGDLSFAAD
      121 TAESYPWKQD LGEASPLGIA TRRTLAREAV GVVGAITPWN FPHQINLAKL GPALAAGNTV
      181 VLKPAPDTPW CAAALGEIIV EHTDFPPGVV NIVTSSSHAL GALLAKDPRV DMISFTGSTA
      241 TGRAVMADAA ATIKKVFLEL GGKSAFVVLD DADLAAASAV SAFSACMHAG QGCAITTRLV
      301 VPRARYEEAV AIAAATMSSI RPGDPNDPGT VCGPLISARQ RDRVQGYLDL AVAEGGRFAC
      361 GGARPADREV GFYIEPTVIA GLTNDARVAR EEIFGPVLTV IAHDGDDDAV RIANDSPYGL
      421 SGTVYGADPQ RAARIASRLR VGTVNVNGGV WYCADAPFGG YKQSGIGREM GLLGFEEYLE
      481 AKLIATAAN
//