LOCUS       SIT99381.1               110 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 HIT
            family protein protein.
ACCESSION   LT708304-793
PROTEIN_ID  SIT99381.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0782C"
                     /note="Mb0782c, -, len: 110 aa. Equivalent to Rv0759c,
                     len: 110 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 110 aa overlap). Conserved
                     hypothetical protein, highly similar (but shorter 45 aa in
                     N-terminus) to P49774|YHIT_MYCLE|ML2237|MLCB5.04c|U296A
                     HYPOTHETICAL HIT-LIKE PROTEIN from Mycobacterium leprae
                     (155 aa), FASTA scores: opt: 766, E(): 0, (78.7% identity
                     in 150 aa overlap). Also highly similar (but N-terminus
                     always shorter) to HIT-like proteins and protein kinase
                     inhibitors e.g. AAF72728.1|AF265258_1|AF265258 HIT-like
                     protein from Rhodococcus sp. (141 aa);
                     NP_212513.1|NC_001318 protein kinase C1 inhibitor (pkcI)
                     from Borrelia burgdorferi (149 aa);
                     P94252|YHIT_BORBU|BB0379 HYPOTHETICAL HIT-LIKE PROTEIN
                     from Borrelia burgdorferi (139 aa); NP_110768.1|NC_002689
                     HIT (histidine triad) family protein from Thermoplasma
                     volcanium (158 aa); P16436|IPK1_BOVIN protein kinase C
                     inhibitor 1 (pkci-1) from Bos taurus (Bovine) (125 aa),
                     FASTA scores: opt: 195, E(): 5.2e-08, (33.3% identity in
                     111 aa overlap); etc. Also shows similarity with
                     Rv2613c|MTCY01A10.20A CONSERVED HYPOTHETICAL PROTEIN from
                     Mycobacterium tuberculosis (195 aa) and Rv1262c|MTCY50.20
                     HYPOTHETICAL HIT-LIKE PROTEIN (144 aa). Protein product
                     from Mb0782c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb0782c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P0A5B6"
                     /db_xref="InterPro:IPR001310"
                     /db_xref="InterPro:IPR011146"
                     /db_xref="InterPro:IPR019808"
                     /db_xref="InterPro:IPR036265"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5B6"
BEGIN
        1 MAFLTIEPMT QGHTLVVPRA EIDHWQNVDP ALFGRVMSVS QLIGKAVCRA FSTQRAGMII
       61 AGLEVPHLHI HVFPTRSLSD FGFANVDRNP SPGSLDEAQA KIRAALAQLA
//