LOCUS       SIT99379.1               247 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            TWO COMPONENT SYSTEM RESPONSE TRANSCRIPTIONAL POSITIVE
            REGULATOR PHOP protein.
ACCESSION   LT708304-791
PROTEIN_ID  SIT99379.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="phoP"
                     /locus_tag="BQ2027_MB0780"
                     /note="Mb0780, phoP, len: 247 aa. Equivalent to Rv0757,
                     len: 247 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 247 aa overlap). Possible phoP, two
                     component system response phosphate regulon
                     transcriptional regulator, highly similar to various
                     transcriptional regulators e.g. CAC32360.1|AL583945
                     putative two component system response regulator from
                     Streptomyces coelicolor (271 aa); T45446 probable
                     two-component response regulator from Mycobacterium leprae
                     (253 aa); and similar to phoP proteins e.g.
                     P13792|PHOP_BACSU alkaline phosphatase synthesis
                     transcription regulatory protein from Bacillus subtilis
                     (240 aa), FASTA scores: opt: 594, E(): 2.3e-33, (41.0%
                     identity in 234 aa overlap); etc. Also highly similar to
                     Rv3765c from Mycobacterium tuberculosis (234 aa), Rv1033c
                     (257 aa), RV0903c|MTCY31.31c|Q10531 (236 aa), FASTA score:
                     (45.4% identity in 229 aa overlap); MTCY10G2_16 and
                     MTU88959_1. Protein product from Mb0780 detected using
                     shotgun mass spectrometry. Mb0780 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XWA9"
                     /db_xref="InterPro:IPR001789"
                     /db_xref="InterPro:IPR001867"
                     /db_xref="InterPro:IPR011006"
                     /db_xref="InterPro:IPR016032"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR039420"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XWA9"
BEGIN
        1 MRKGVDLVTA GTPGENTTPE ARVLVVDDEA NIVELLSVSL KFQGFEVYTA TNGAQALDRA
       61 RETRPDAVIL DVMMPGMDGF GVLRRLRADG IDAPALFLTA RDSLQDKIAG LTLGGDDYVT
      121 KPFSLEEVVA RLRVILRRAG KGNKEPRNVR LTFADIELDE ETHEVWKAGQ PVSLSPTEFT
      181 LLRYFVINAG TVLSKPKILD HVWRYDFGGD VNVVESYVSY LRRKIDTGEK RLLHTLRGVG
      241 YVLREPR
//