LOCUS       SIT99374.1               510 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE MMSA (METHYLMALONIC
            ACID SEMIALDEHYDE DEHYDROGENASE) (MMSDH) protein.
ACCESSION   LT708304-786
PROTEIN_ID  SIT99374.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mmsA"
                     /locus_tag="BQ2027_MB0775C"
                     /note="Mb0775c, mmsA, len: 510 aa. Equivalent to Rv0753c,
                     len: 510 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 510 aa overlap). Probable mmsA,
                     methylmalonic acid semialdehyde dehydrogenase (EC
                     1.2.1.27), highly similar to others e.g.
                     NP_420115.1|NC_002696 putative methylmalonate-semialdehyde
                     dehydrogenase from Caulobacter crescentus (499 aa);
                     L48550|STMMSDA_1|CAB75315.1|AL139164 methylmalonic acid
                     semialdehyde dehydrogenase from Streptomyces coelicolor
                     (500 aa), FASTA score: (51.6% identity in 498 aa overlap);
                     M84911|PSEMMSRAB_2|NP_252260.1|NC_002516
                     methylmalonate-semialdehyde dehydrogenase from Pseudomonas
                     aeruginosa (497 aa), FASTA scores: opt: 1127, E(): 0,
                     (47.9% identity in 507 aa overlap); etc. Note that also
                     highly similar to malonic semialdehyde oxidative
                     decarboxylases e.g. NP_104968.1|NC_002678 malonic
                     semialdehyde oxidative decarboxylase from Mesorhizobium
                     loti (498 aa); NP_384832.1|NC_003047 PUTATIVE MALONIC
                     SEMIALDEHYDE OXIDATIVE DECARBOXYLASE PROTEIN from
                     Sinorhizobium meliloti (498 aa); etc. Contains PS00070
                     Aldehyde dehydrogenases cysteine active site. BELONGS TO
                     THE ALDEHYDE DEHYDROGENASES FAMILY. Protein product from
                     Mb0775c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb0775c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XWE3"
                     /db_xref="InterPro:IPR010061"
                     /db_xref="InterPro:IPR015590"
                     /db_xref="InterPro:IPR016160"
                     /db_xref="InterPro:IPR016161"
                     /db_xref="InterPro:IPR016162"
                     /db_xref="InterPro:IPR016163"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XWE3"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MTTQISHFID GQRTAGQSTR SADVFDPNTG QIQAKVPMAG KSDIDAAVAS AVEAQKGWAA
       61 WNPQRRARVL MRFIELVNDT IDELAELLSR EHGKTLADAR GDVQRGIEVI EFCLGIPHLL
      121 KGEYTEGAGP GIDVYSLRQP LGVVAGITPF NFPAMIPLWK AGPALACGNA FVLKPSERDP
      181 SVPVRLAELF IEAGLPAGVF QVVHGDKEAV DAILHHPDIK AVGFVGSSDI AQYIYAGAAA
      241 TGKRAQCFGG AKNHMIVMPD ADLDQAVDAL IGAGYGSAGE RCMAISVAVP VGDQTAERLR
      301 ARLIERINNL RVGHSLDPKA DYGPLVTGAA LARVRDYIGQ GVAAGAELVV DGRDRASDDL
      361 TFGLPEGDAN LEGGFFIGPT LFDHVAAHMS IYTDEIFGPV LCMVRARDYE EALRLPSEHE
      421 YGNGVAIFTR DGDAARDFVS RGQVGMVGVN VPIPVPVAYH TFGGWKRSGF GDLNQHGPAA
      481 IQFYTKVKTV TSRWPSGIKD GAEFVIPTMS
//