LOCUS       SIT99357.1               165 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            TRANSCRIPTIONAL REGULATORY PROTEIN protein.
ACCESSION   LT708304-769
PROTEIN_ID  SIT99357.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0758"
                     /note="Mb0758, -, len: 165 aa. Equivalent to Rv0737, len:
                     165 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 165 aa overlap). Possible
                     transcriptional regulator, similar to others e.g.
                     BAB69161.1|AB070937 regulator protein from Streptomyces
                     avermitilis (169 aa); NP_419731.1|NC_002696
                     transcriptional regulator MarR family from Caulobacter
                     crescentus (148 aa) (homology only at C-terminus); etc.
                     Also shows weak similarity to AB0014|AB001488_14
                     hypothetical protein from Bacillus subtilis (164 aa),
                     FASTA scores: opt: 163, E(): 9.3e-05, (32.8% identity in
                     116 aa overlap), which is similar to slyY gene of S.
                     typhimurium required for survival in macrophage. Contains
                     possible helix-turn helix motif from aa 73-94 (Score 1138,
                     +3.06 SD). Protein product from Mb0758 detected using
                     SWATH mass spectrometry. Mb0758 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XWB9"
                     /db_xref="InterPro:IPR000835"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR036390"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XWB9"
BEGIN
        1 MASDNRDPIA AARANWERSG WGDVSLGMVA VTSVMRAHQI LLARVETALR PYDLSFSRFE
       61 LLRLLAFSRI GALPITKASD RLQVHVTSVT HAIRRLEADG LVRRVPHPTD GRTTLVQITE
      121 LGRSTVEDAT VTLNEQVFAN VGMGAEESQA LVSAVETLRR NAGDF
//