LOCUS SIT99357.1 165 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN protein. ACCESSION LT708304-769 PROTEIN_ID SIT99357.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB0758" /note="Mb0758, -, len: 165 aa. Equivalent to Rv0737, len: 165 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 165 aa overlap). Possible transcriptional regulator, similar to others e.g. BAB69161.1|AB070937 regulator protein from Streptomyces avermitilis (169 aa); NP_419731.1|NC_002696 transcriptional regulator MarR family from Caulobacter crescentus (148 aa) (homology only at C-terminus); etc. Also shows weak similarity to AB0014|AB001488_14 hypothetical protein from Bacillus subtilis (164 aa), FASTA scores: opt: 163, E(): 9.3e-05, (32.8% identity in 116 aa overlap), which is similar to slyY gene of S. typhimurium required for survival in macrophage. Contains possible helix-turn helix motif from aa 73-94 (Score 1138, +3.06 SD). Protein product from Mb0758 detected using SWATH mass spectrometry. Mb0758 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XWB9" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/TrEMBL:A0A1R3XWB9" BEGIN 1 MASDNRDPIA AARANWERSG WGDVSLGMVA VTSVMRAHQI LLARVETALR PYDLSFSRFE 61 LLRLLAFSRI GALPITKASD RLQVHVTSVT HAIRRLEADG LVRRVPHPTD GRTTLVQITE 121 LGRSTVEDAT VTLNEQVFAN VGMGAEESQA LVSAVETLRR NAGDF //