LOCUS       SIT99349.1               448 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            D-XYLULOSE KINASE XYLB (XYLULOKINASE) (XYLULOSE KINASE)
            protein.
ACCESSION   LT708304-761
PROTEIN_ID  SIT99349.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="xylB"
                     /locus_tag="BQ2027_MB0750"
                     /note="Mb0750, xylB, len: 448 aa. Equivalent to Rv0729,
                     len: 448 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 448 aa overlap). Possible xylB,
                     D-xylulose-kinase (xylulokinase) (EC 2.7.1.17). C-terminus
                     highly similar to AAD09880.1|U77912 unknown protein from
                     Mycobacterium bovis (102 aa); and N-terminus highly
                     similar to T45387|Z98756|MLCB2492_25 hypothetical protein
                     from Mycobacterium leprae (110 aa), FASTA scores: opt:
                     427, E(): 1.1e-19, (60.9% identity in 110 aa overlap).
                     Also similar to xylA/xylB genes from various bacterial
                     species e.g. AAC26499.1|AF045245 D-xylulose-kinase from
                     Klebsiella pneumoniae (487 aa); NP_418021.1|NC_000913
                     xylulokinase from Escherichia coli strain K12 (484 aa),
                     FASTA scores: opt: 260, E(): 7.5e-09, (25.9% identity in
                     478 aa overlap); etc. Also similar to Rv3696c|glpK
                     PROBABLE GLYCEROL KINASE (EC 2.7.1.30) from Mycobacterium
                     tuberculosis (517 aa). BELONGS TO THE FUCOKINASE /
                     GLUCONOKINASE / GLYCEROKINASE / XYLULOKINASE FAMILY.
                     Protein product from Mb0750 detected using SWATH mass
                     spectrometry. Mb0750 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XW81"
                     /db_xref="InterPro:IPR000577"
                     /db_xref="InterPro:IPR018484"
                     /db_xref="InterPro:IPR018485"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XW81"
BEGIN
        1 MSRDDVTIGI DIGTTAVKAV AADDNGRVTA RVRIGHQLAV PAPDRLEHDA DEAWRRGPLA
       61 ALDRLVGPDT RALAVAAMVP SLTAVDPAGR PITPGLLYGD ARGRVPNASV ARAQSVPSVG
      121 ETAEFLRWTA GQAPDASGYW PAPAVANYAL SGEAVIDYAT AVTTLPLFDG TGWNATACAD
      181 CGVTVDRMPR VETFGVGVGQ VRGTGAVLAV GAVDALCEQI VAGADRDGDV LVLCGATLIV
      241 WTTISAARQV PGLWTIPHTA PGKSQIGGAS NAGGLFLNWV DRVIGPGDPA LADPRRVPVW
      301 LPYIRGERTP FHEPDRRAVL DGVDLSQDAA SVRRAAYEAS GFVVRQLIEL SGAPVARIVA
      361 AGGGTRIQPW MQAIADATGR PVEVSRVAEG AALGAAFLGR LAAGLESSIA DAARWASTDR
      421 IVEPSADWAG PTKERYRRFL ALSGSKLA
//