LOCUS       SIT99304.1               275 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 probable
            short-chain type dehydrogenase/reductase protein.
ACCESSION   LT708304-716
PROTEIN_ID  SIT99304.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0706"
                     /note="Mb0706, -, len: 275 aa. Equivalent to Rv0687, len:
                     275 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 275 aa overlap). Probable short-chain
                     dehydrogenase/reductase (EC 1.-.-.-), highly similar to
                     various dehydrogenases (generally SDR family) e.g.
                     U17129|RSU17129_7 short-chain dehydrogenase from
                     Rhodococcus erythropolis (275 aa), FASTA scores: opt:
                     1112, E(): 0, (61.2% identity in 268 aa overlap);
                     MMU34072_2 steroid dehydrogenase from Musmus culus (260
                     aa), FASTA scores: opt: 390, E(): 2.2e-17, (34.1% identity
                     in 267 aa overlap); etc. Also similar to
                     MTV002_16|O33292|Rv2750 DEHYDROGENASE from Mycobacterium
                     tuberculosis (272 aa). Contains PS00061 Short-chain
                     alcohol dehydrogenase family signature. Protein product
                     from Mb0706 detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb0706 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XW77"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR020904"
                     /db_xref="InterPro:IPR023985"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XW77"
BEGIN
        1 MSARGGSLHG RVAFVTGAAR AQGRSHAVRL AREGADIVAL DICAPVSGSV TYPPATSEDL
       61 GETVRAVEAE GRKVLAREVD IRDDAELRRL VADGVEQFGR LDIVVANAGV LGWGRLWELT
      121 DEQWETVIGV NLTGTWRTLR ATVPAMIDAG NGGSIVVVSS SAGLKATPGN GHYAASKHAL
      181 VALTNTLAIE LGEFGIRVNS IHPYSVDTPM IEPEAMIQTF AKHPGYVHSF PPMPLQPKGF
      241 MTPDEISDVV VWLAGDGSGA LSGNQIPVDK GALKY
//