LOCUS       SIT99298.1               196 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            TRANSCRIPTIONAL REGULATORY PROTEIN (POSSIBLY TETR-FAMILY)
            protein.
ACCESSION   LT708304-710
PROTEIN_ID  SIT99298.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0700"
                     /note="Mb0700, -, len: 196 aa. Equivalent to Rv0681, len:
                     196 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 196 aa overlap). Probable
                     transcription regulator, TetR family, similar to others
                     and especially many tetracycline repressors e.g. T34657
                     probable transcription regulator from Streptomyces
                     coelicolor (189 aa);
                     AF0278|AF027868_40|NP_389788.1|NC_000964 yobS regulator
                     from Bacillus subtilis (191 aa), FASTA scores: opt: 213,
                     E(): 1.6e-07, (28.8% identity in 153 aa overlap);
                     P09164|TER4_ECOLI TETRACYCLINE REPRESSOR PROTEIN from
                     Escherichia coli (217 aa), FASTA scores: opt: 145, E():
                     0.0068, (39.0% identity in 59 aa overlap); etc. Contains
                     helix-turn-helix motif at aa 28-49 (Score 1020, +2.66 SD).
                     Protein product from Mb0700 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0700 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3XW36"
                     /db_xref="InterPro:IPR001647"
                     /db_xref="InterPro:IPR009057"
                     /db_xref="InterPro:IPR025996"
                     /db_xref="InterPro:IPR036271"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XW36"
BEGIN
        1 MARPAKLSRE SIVEGALTFL DREGWDSLTI NALATQLGTK GPSLYNHVDS LEDLRRAVRI
       61 RVIDDIITML NRVGAGRARD DAVLVMAGAY RSYAHHHPGR YSAFTRMPLG GDDPEYTAAT
      121 RGAAAPVIAV LSSYGLDGEQ AFYAALEFWS ALHGFVLLEM TGVMDDIDTD AVFTDMVLRL
      181 AAGMERRTTH GGTAST
//