LOCUS       SIT99293.1               964 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED TRANSMEMBRANE TRANSPORT PROTEIN MMPL5 protein.
ACCESSION   LT708304-705
PROTEIN_ID  SIT99293.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mmpL5"
                     /locus_tag="BQ2027_MB0695C"
                     /note="Mb0695c, mmpL5, len: 964 aa. Equivalent to Rv0676c,
                     len: 964 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 964 aa overlap). Probable mmpL5,
                     conserved transmembrane transport protein (see first
                     citation below), member of RND superfamily, highly similar
                     to other Mycobacterial proteins e.g. MTV037_14, MTCY98_8,
                     MTCY20G9_34, MTCY4D9_15, MTCY48_8, MTCY19G5_6, MTV005_19,
                     etc. Also similar to other Mycobacterial mmpl proteins
                     e.g. P54881|MML4_MYCLE PUTATIVE MEMBRANE PROTEIN MMPL4
                     from Mycobacterium leprae (959 aa), FASTA scores: opt:
                     3991, E(): 0, (62.8% identity in 933 aa overlap); etc.
                     BELONGS TO THE MMPL FAMILY. TBparse score is 0.884.
                     Protein product from Mb0695c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0695c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:A0A1R3XX34"
                     /db_xref="InterPro:IPR004707"
                     /db_xref="InterPro:IPR004869"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XX34"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MIVQRTAAPT GSVPPDRHAA RPFIPRMIRT FAVPIILGWL VTIAVLNVTV PQLETVGQIQ
       61 AVSMSPDAAP SMISMKHIGK VFEEGDSDSA AMIVLEGQRP LGDAAHAFYD QMIGRLQADT
      121 THVQSLQDFW GDPLTATGAQ SSDGKAAYVQ VKLAGNQGES LANESVEAVK TIVERLAPPP
      181 GVKVYVTGSA ALVADQQQAG DRSLQVIEAV TFTVIIVMLL LVYRSIITSA IMLTMVVLGL
      241 LATRGGVAFL GFHRIIGLST FATNLLVVLA IAAATDYAIF LIGRYQEARG LGQDRESAYY
      301 TMFGGTAHVV LGSGLTIAGA TFCLSFTRLP YFQTLGVPLA IGMVIVVAAA LTLGPAIIAV
      361 TSRFGKLLEP KRMARVRGWR KVGAAIVRWP GPILVGAVAL ALVGLLTLPG YRTNYNDRNY
      421 LPADLPANEG YAAAERHFSQ ARMNPEVLMV ESDHDMRNSA DFLVINKIAK AIFAVEGISR
      481 VQAITRPDGK PIEHTSIPFL ISMQGTSQKL TEKYNQDLTA RMLEQVNDIQ SNIDQMERMH
      541 SLTQQMADVT HEMVIQMTGM VVDVEELRNH IADFDDFFRP IRSYFYWEKH CYDIPVCWSL
      601 RSVFDTLDGI DVMTEDINNL LPLMQRLDTL MPQLTAMMPE MIQTMKSMKA QMLSMHSTQE
      661 GLQDQMAAMQ EDSAAMGEAF DASRNDDSFY LPPEVFDNPD FQRGLEQFLS PDGHAVRFII
      721 SHEGDPMSQA GIARIAKIKT AAKEAIKGTP LEGSAIYLGG TAAMFKDLSD GNTYDLMIAG
      781 ISALCLIFII MLIITRSVVA AAVIVGTVVL SLGASFGLSV LIWQHILGIE LHWLVLAMAV
      841 IILLAVGADY NLLLVARLKE EIHAGINTGI IRAMGGSGSV VTAAGLVFAF TMMSFAVSEL
      901 TVMAQVGTTI GMGLLFDTLI VRSFMTPSIA ALLGKWFWWP QVVRQRPVPQ PWPSPASART
      961 FALV
//