LOCUS       SIT99272.1               359 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            RIBONUCLEOTIDE-TRANSPORT ATP-BINDING PROTEIN ABC TRANSPORTER
            MKL protein.
ACCESSION   LT708304-684
PROTEIN_ID  SIT99272.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mkl"
                     /locus_tag="BQ2027_MB0674"
                     /note="Mb0674, mkl, len: 359 aa. Equivalent to Rv0655,
                     len: 359 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 359 aa overlap). Possible mkl,
                     ribonucleotide-transport ATP-binding protein ABC
                     transporter (see first citation below), equivalent to
                     P30769|MKL_MYCLE|ML1892 POSSIBLE RIBONUCLEOTIDE TRANSPORT
                     ATP-BINDING PROTEIN from Mycobacterium leprae (347 aa),
                     FASTA scores: opt: 2021, E(): 0, (92.2% identity in 335 aa
                     overlap). Also highly similar to many e.g.
                     AB92896.1|AL356992 putative ABC-transporter ATP-binding
                     protein from Streptomyces coelicolor (343 aa);
                     NP_253146.1|NC_002516 probable ATP-binding component of
                     ABC transporter from Pseudomonas aeruginosa (269 aa);
                     P45393|YRBF_ECOLI hypothetical ABC transporter ATP-binding
                     protein from Escherichia coli (269 aa), FASTA scores: opt:
                     644, E(): 3.4e-33, (38.5% identity in 244 aa overlap);
                     etc. Also similar to many other Mycobacterium tuberculosis
                     ABC transporters e.g. P71747|CYSA|Rv2397c|MTCY253.24 (351
                     aa), FASTA score: (33.6% identity in 241 aa overlap).
                     Contains PS00017 ATP/GTP-binding site motif A (P-loop),
                     PS00211 ABC transporters family signature. BELONGS TO THE
                     ATP-BINDING TRANSPORT PROTEIN FAMILY (ABC TRANSPORTERS).
                     Protein product from Mb0674 detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0674 found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="GOA:P63358"
                     /db_xref="InterPro:IPR003439"
                     /db_xref="InterPro:IPR003593"
                     /db_xref="InterPro:IPR017871"
                     /db_xref="InterPro:IPR027417"
                     /db_xref="InterPro:IPR030296"
                     /db_xref="UniProtKB/Swiss-Prot:P63358"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MRYSDSYHTT GRWQPRASTE GFPMGVSIEV NGLTKSFGSS RIWEDVTLTI PAGEVSVLLG
       61 PSGTGKSVFL KSLIGLLRPE RGSIIIDGTD IIECSAKELY EIRTLFGVLF QDGALFGSMN
      121 LYDNTAFPLR EHTKKKESEI RDIVMEKLAL VGLGGDEKKF PGEISGGMRK RAGLARALVL
      181 DPQIILCDEP DSGLDPVRTA YLSQLIMDIN AQIDATILIV THNINIARTV PDNMGMLFRK
      241 HLVMFGPREV LLTSDEPVVR QFLNGRRIGP IGMSEEKDEA TMAEEQALLD AGHHAGGVEE
      301 IEGVPPQISA TPGMPERKAV ARRQARVREM LHTLPKKAQA AILDDLEGTH KYAVHEIGQ
//