LOCUS       SIT99271.1               501 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            DIOXYGENASE protein.
ACCESSION   LT708304-683
PROTEIN_ID  SIT99271.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0673"
                     /note="Mb0673, -, len: 501 aa. Equivalent to Rv0654, len:
                     501 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 501 aa overlap). Probable dioxygenase
                     (EC 1.-.-.-), highly similar to others eg
                     AAK06796.1|AF324838_15|AF324838|SimC5 putative dioxygenase
                     (involved in tetraene formation) from Streptomyces
                     antibioticus (456 aa); CAB56138.1| AL117669 putative
                     dioxygenase from Streptomyces coelicolor (503 aa); T51734
                     neoxanthin cleavage enzyme (9-cis-epoxy-carotenoid
                     dioxygenase) from Arabidopsis thaliana (538 aa); Q53353
                     LIGNOSTILBENE-ALPHA,BETA-DIOXYGENASE from Pseudomonas
                     paucimobilis (Sphingomonas paucimobilis), FASTA scores:
                     opt: 280, E(): 2.3e-11, (28.5% identity in 523 aa
                     overlap); etc. Also some similarity with
                     Rv0913c|MTCY21C12.07c POSSIBLE DIOXYGENASE from
                     Mycobacterium tuberculosis (501 aa), FASTA score: (29.5%
                     identity in 522 aa overlap). Protein product from Mb0673
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0673 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XW04"
                     /db_xref="InterPro:IPR004294"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XW04"
BEGIN
        1 MTTAQAAESQ NPYLEGFLAP VSTEVTATDL PVTGRIPEHL DGRYLRNGPN PVAEVDPATY
       61 HWFTGDAMVH GVALRDGKAR WYRNRWVRTP AVCAALGEPI SARPHPRTGI IEGGPNTNVL
      121 THAGRTLALV EAGVVNYELT DELDTVGPCD FDGTLHGGYT AHPQRDPHTG ELHAVSYSFA
      181 RGHRVQYSVI GTDGHARRTV DIEVAGSPMM HSFSLTDNYV VIYDLPVTFD PMQVVPASVP
      241 RWLQRPARLV IQSVLGRVRI PDPIAALGNR MQGHSDRLPY AWNPSYPARV GVMPREGGNE
      301 DVRWFDIEPC YVYHPLNAYS ECRNGAEVLV LDVVRYSRMF DRDRRGPGGD SRPSLDRWTI
      361 NLATGAVTAE CRDDRAQEFP RINETLVGGP HRFAYTVGIE GGFLVGAGAA LSTPLYKQDC
      421 VTGSSTVASL DPDLLIGEMV FVPNPSARAE DDGILMGYGW HRGRDEGQLL LLDAQTLESI
      481 ATVHLPQRVP MGFHGNWAPT T
//