LOCUS       SIT99260.1               293 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 METHOXY
            MYCOLIC ACID SYNTHASE 3 MMAA3 (METHYL MYCOLIC ACID SYNTHASE
            3) (MMA3) (HYDROXY MYCOLIC ACID SYNTHASE) protein.
ACCESSION   LT708304-672
PROTEIN_ID  SIT99260.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mmaA3"
                     /locus_tag="BQ2027_MB0662C"
                     /note="Mb0662c, mmaA3, len: 293 aa. Equivalent to Rv0643c,
                     len: 293 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 293 aa overlap). mmaA3, methoxy
                     mycolic acid synthase 3 (methyltransferase) (EC 2.1.1.-)
                     (see citations below). Equivalent to
                     AAC44875|AAC44875.1|cmaB methyl transferase (mycolic acid
                     modification protein) from Mycobacterium bovis BCG strain
                     Pasteur (289 aa); and highly similar to others from
                     Mycobacteria e.g. upstream ORF
                     P72028|mmaA4|Rv0642c|MTCY20H10.23c PUTATIVE METHOXY
                     MYCOLIC ACID SYNTHASE 4 from Mycobacterium tuberculosis
                     (301 aa). Protein product from Mb0662c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb0662c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:Q7U1K0"
                     /db_xref="InterPro:IPR003333"
                     /db_xref="InterPro:IPR029063"
                     /db_xref="UniProtKB/Swiss-Prot:Q7U1K0"
BEGIN
        1 MSDNSTGTTK SRSNVDDVQA HYDLSDAFFA LFQDPTRTYS CAYFERDDMT LHEAQVAKLD
       61 LTLGKLGLEP GMTLLDVGCG WGSVMKRAVE RYDVNVVGLT LSKNQHAYCQ QVLDKVDTNR
      121 SHRVLLSDWA NFSEPVDRIV TIEAIEHFGF ERYDDFFKFA YNAMPADGVM LLHSITGLHV
      181 KQVIERGIPL TMEMAKFIRF IVTDIFPGGR LPTIETIEEH VTKAGFTITD IQSLQPHFAR
      241 TLDLWAEALQ AHKDEAIEIQ SAEVYERYMK YLTGCAKAFR MGYIDCNQFT LAK
//