LOCUS       SIT99252.1               158 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 (3r)
            -hydroxyacyl-acp dehydratase subunit hada protein.
ACCESSION   LT708304-664
PROTEIN_ID  SIT99252.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="hadA"
                     /locus_tag="BQ2027_MB0654"
                     /note="Mb0654, -, len: 158 aa. Equivalent to Rv0635, len:
                     158 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 158 aa overlap). Conserved
                     hypothetical protein, equivalent to NP_302287.1|NC_002677
                     conserved hypothetical protein from Mycobacterium leprae
                     (159 aa); and highly similar to YV31_MYCLE|P54879
                     conserved hypothetical protein from Mycobacterium leprae
                     (166 aa), FASTA scores: opt: 387, E(): 5.9e-21, (43.4%
                     identity in 145 aa overlap). Also similar
                     CAB77410.1|AL160431|SCD82.07 hypothetical protein from
                     Streptomyces coelicolor (150 aa). And highly similar to
                     two hypothetical proteins from Mycobacterium tuberculosis:
                     Rv0504c|YV31_MYCTU|Q11168 (166 aa), FASTA scores: opt:
                     405, E(): 3.2e-22, (45.0% identity in 140 aa overlap); and
                     Rv0637|MTY20H10_19 (2 ORFs downstream) (166 aa), FASTA
                     score: (48.7% identity in 150 aa overlap). Protein product
                     from Mb0654 detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb0654 found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR016709"
                     /db_xref="InterPro:IPR029069"
                     /db_xref="InterPro:IPR039569"
                     /db_xref="UniProtKB/Swiss-Prot:Q7U1K4"
BEGIN
        1 MALSADIVGM HYRYPDHYEV EREKIREYAV AVQNDDAWYF EEDGAAELGY KGLLAPLTFI
       61 CVFGYKAQAA FFKHANIATA EAQIVQVDQV LKFEKPIVAG DKLYCDVYVD SVREAHGTQI
      121 IVTKNIVTNE EGDLVQETYT TLAGRAGEDG EGFSDGAA
//