LOCUS SIT99245.1 897 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE EXONUCLEASE V (BETA CHAIN) RECBA [FIRST PART] (EXODEOXYRIBONUCLEASE V BETA CHAIN)(EXODEOXYRIBONUCLEASE V POLYPEPTIDE) protein. ACCESSION LT708304-657 PROTEIN_ID SIT99245.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="recBa" /locus_tag="BQ2027_MB0647C" /note="Mb0647c, recBa, len: 897 aa. Equivalent to 5' end of Rv0630c, len: 1094 aa, from Mycobacterium tuberculosis strain H37Rv, (99.2% identity in 868 aa overlap). Probable recB, exonuclease V, beta chain (exodeoxyribonuclease V, beta chain) (EC 3.1.11.5), highly similar to other exonucleases e.g. AF157643_2|recB|AAD46808.1 Escherichia coli RecB protein homolog from Mycobacterium smegmatis (1083 aa); P08394|EX5B_ECOLI|RORA|B2820 exodeoxyribonuclease v 135 kd polypeptide (EC 3.1.11.5) (EXONUCLEASE V BETA CHAIN) from Escherichia coli strain K12 (1180 aa), FASTA scores: opt: 289, E(): 4.3e-11, (29.5 identity in 1059 aa overlap); etc. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE HELICASE FAMILY, UVRD SUBFAMILY. CONSIST OF THREE SUBUNITS; RECB, RECC|Rv0631c AND RECD|Rv0629c. REMARK-M.bovis-M.tuberculosis: In Mycobacterium tuberculosis strain H37Rv, recB exists as a single gene. In Mycobacterium bovis, a frameshift due to a single base deletion (g-*) splits recB into 2 parts, recBa and recBb." /db_xref="GOA:A0A1R3XWD4" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR004586" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="UniProtKB/TrEMBL:A0A1R3XWD4" BEGIN 1 MDRFELLGPL PREGTTTVLE ASAGTGKTFA LAGLVTRYLA ETAATLDEML LITFNRAASR 61 ELRERVRGQI VEALGALQGD APPSGELVEH LLRGSDAERA QKRSRLRDAL ANFDAATIAT 121 THEFCGSVLK SLGVAGDNAA DVELKESLTD LVTEIVDDRY LANFGRQETD PELTYAEALA 181 LALAVVDDPC AQLRPPDPEP GSKAAVRLRF AAEVLEELER RKGRLRAQGF NDLLIRLATA 241 LEAADSPARD RMRERWRIVL VDEFQDTDPM QWRVLERAFS RHSALILIGD PKQAIYGFRG 301 GDIHTYLKAA GTADARYTLG VNWRSDRALV ESLQTVLRDA TLGHADIVVR GTDAHHAGHR 361 LASAPRPAPF RLRVVKRHTL GYDGTAHVPI EALRRHIPDD LAADVAALLA SGATFAGRPV 421 VAADIAVIVE HHKDARACRN ALAEAGIPAI YTGDTDVFAS QAAKDWLCLL EAFDAPQRSG 481 LVRAAACTMF FGETAESLAA EGDALTDRVA GTLREWADHA RHRGVAAVFQ AAQLAGMGRR 541 VLSQRGGERD LTDLAHIAQL LHEAAHRERL GLPGLRDWLR RQAKAGAGPP EHNRRLDSDA 601 AAVQIMTVFV AKGLQFPIVY LPFAFNRNVR SDDILLYHDD GTRCLYIGGK DGGAQRRTVE 661 GLNRVEAAHD NLRLTYVALT RAQSQVVAWW APTFDEVNGG LSRLLRGRRP GQSQVPDRCT 721 PRVTDEQAWA VFAQWEAAGG PSVEESVIGA RSSLEKPVPV PGFEVRHFHR RIDTTWRRTS 781 YSDLVRGSEA VTVTSEPAAG GRADEVEIAV FAAPGSGADL TSPLAALPSG ASFGSLVHAV 841 LETADPAAPD LAAELEAQVP GTRRGGPWTS TTRSWLPNWP ERCCRCTTRR WDPPPPH //