LOCUS       SIT98450.1               425 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 serine
            hydroxymethyltransferase glya2 (serine methylase 2) (shmt
            2) protein.
ACCESSION   LT708304-72
PROTEIN_ID  SIT98450.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="glyA2"
                     /locus_tag="BQ2027_MB0071C"
                     /note="Mb0071c, glyA2, len: 425 aa. Equivalent to Rv0070c,
                     len: 425 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.8% identity in 425 aa overlap). Probable glyA2, serine
                     hydroxymethyltransferase (EC 2.1.2.1), equivalent to
                     NP_302318.1|NC_002677 serine hydroxymethyltransferase from
                     Mycobacterium leprae (426 aa). Also highly similar to many
                     e.g. O86565|GLYA_STRCO SERINE HYDROXYMETHYLTRANSFERASE
                     from Streptomyces coelicolor (420 aa);
                     AAK60516.1|AF327063_1|AF327063 serine
                     hydroxymethyltransferase from Corynebacterium glutamicum
                     (434 aa); GLYA_ECOLI|P00477 serine
                     hydroxymethyltransferase from Escherichia coli (417 aa),
                     FASTA scores: opt: 1462, E(): 0, (54.3% identity in 416 aa
                     overlap); etc. Also highly similar to MTV017_46 from
                     Mycobacterium tuberculosis. Contains PS00096 Serine
                     hydroxymethyltransferase pyridoxal-phosphate attachment
                     site. BELONGS TO THE SHMT FAMILY. COFACTOR: PYRIDOXAL
                     PHOSPHATE. Protein product from Mb0071c detected using
                     shotgun mass spectrometry and SWATH mass spectrometry.
                     Mb0071c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:Q7U2X3"
                     /db_xref="InterPro:IPR001085"
                     /db_xref="InterPro:IPR015421"
                     /db_xref="InterPro:IPR015422"
                     /db_xref="InterPro:IPR015424"
                     /db_xref="InterPro:IPR019798"
                     /db_xref="InterPro:IPR039429"
                     /db_xref="UniProtKB/Swiss-Prot:Q7U2X3"
BEGIN
        1 MNTLNDSLTA FDPDIAALID GELRRQESGL EMIASENYAP LAVMQAQGSV LTNKYAEGYP
       61 GRRYYGGCEF VDGVEQLAID RVKALFGAEY ANVQPHSGAT ANAATMHALL NPGDTILGLS
      121 LAHGGHLTHG MRINFSGKLY HATAYEVSKE DYLVDMDAVA EAARTHRPKM IIAGWSAYPR
      181 QLDFARFRAI ADEVDAVLMV DMAHFAGLVA AGVHPSPVPH AHVVTSTTHK TLGGPRGGII
      241 LCNDPAIAKK INSAVFPGQQ GGPLGHVIAA KATAFKMAAQ PEFAQRQQRC LDGARILAGR
      301 LTQPDVAERG IAVLTGGTDV HLVLVDLRDA ELDGQQAEDR LAAVDITVNR NAVPFDPRPP
      361 MITSGLRIGT PALAARGFSH NDFRAVADLI AAALTATNDD QLGPLRAQVQ RLAARYPLYP
      421 ELHRT
//