LOCUS SIT98448.1 461 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE L-SERINE DEHYDRATASE SDAA (L-SERINE DEAMINASE) (SDH) ( L-SD) protein. ACCESSION LT708304-71 PROTEIN_ID SIT98448.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="sdaA" /locus_tag="BQ2027_MB0070C" /note="Mb0070c, sdaA, len: 461 aa. Equivalent to Rv0069c, len: 461 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 461 aa overlap). Probable sdaA, L-serine dehydratase (EC 4.3.1.17), equivalent to NP_302203.1| NC_002677 L-serine dehydratase from Mycobacterium leprae (458 aa). Also highly similar to many e.g. NP_251133.1|NC_002516 L-serine dehydratase from Pseudomonas aeruginosa (458 aa); O86564|SDHL_STRCO L-SERINE DEHYDRATASE from Streptomyces coelicolor (455 aa); SDHL_ECOLI|P16095 L-serine dehydratase 1 from Escherichia coli (454 aa), FASTA scores: opt: 1381, E(): 0, (51.1% identity in 460 aa overlap); etc. BELONGS TO THE IRON-SULFUR DEPENDENT L-SERINE DEHYDRATASE FAMILY. COFACTOR: IRON-SULFUR (4FE-4S) (PROBABLE). Protein product from Mb0070c detected using SWATH mass spectrometry. Mb0070c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:P66774" /db_xref="InterPro:IPR004644" /db_xref="InterPro:IPR005130" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="UniProtKB/Swiss-Prot:P66774" BEGIN 1 MTISVFDLFT IGIGPSSSHT VGPMRAANQF VVALRRRGHL DDLEAMRVDL FGSLAATGAG 61 HGTMSAILLG LEGCQPETIT TEHKERRLAE IAASGVTRIG GVIPVPLTER DIDLHPDIVL 121 PTHPNGMTFT AAGPHGRVLA TETYFSVGGG FIVTEQTSGN SGQHPCSVAL PYVSAQELLD 181 ICDRLDVSIS EAALRNETCC RTENEVRAAL LHLRDVMVEC EQRSIAREGL LPGGLRVRRR 241 AKVWYDRLNA EDPTRKPEFA EDWVNLVALA VNEENASGGR VVTAPTNGAA GIVPAVLHYA 301 IHYTSAGAGD PDDVTVRFLL TAGAIGSLFK ERASISGAEV GCQGEVGSAA AMAAAGLAEI 361 LGGTPRQVEN AAEIAMEHSL GLTCDPIAGL VQIPCIERNA ISAGKAINAA RMALRGDGIH 421 RVTLDQVIDT MRATGADMHT KYKETSAGGL AINVAVNIVE C //