LOCUS       SIT98448.1               461 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            L-SERINE DEHYDRATASE SDAA (L-SERINE DEAMINASE) (SDH) (
            L-SD) protein.
ACCESSION   LT708304-71
PROTEIN_ID  SIT98448.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="sdaA"
                     /locus_tag="BQ2027_MB0070C"
                     /note="Mb0070c, sdaA, len: 461 aa. Equivalent to Rv0069c,
                     len: 461 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 461 aa overlap). Probable sdaA,
                     L-serine dehydratase (EC 4.3.1.17), equivalent to
                     NP_302203.1| NC_002677 L-serine dehydratase from
                     Mycobacterium leprae (458 aa). Also highly similar to many
                     e.g. NP_251133.1|NC_002516 L-serine dehydratase from
                     Pseudomonas aeruginosa (458 aa); O86564|SDHL_STRCO
                     L-SERINE DEHYDRATASE from Streptomyces coelicolor (455
                     aa); SDHL_ECOLI|P16095 L-serine dehydratase 1 from
                     Escherichia coli (454 aa), FASTA scores: opt: 1381, E():
                     0, (51.1% identity in 460 aa overlap); etc. BELONGS TO THE
                     IRON-SULFUR DEPENDENT L-SERINE DEHYDRATASE FAMILY.
                     COFACTOR: IRON-SULFUR (4FE-4S) (PROBABLE). Protein product
                     from Mb0070c detected using SWATH mass spectrometry.
                     Mb0070c found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing."
                     /db_xref="GOA:P66774"
                     /db_xref="InterPro:IPR004644"
                     /db_xref="InterPro:IPR005130"
                     /db_xref="InterPro:IPR005131"
                     /db_xref="InterPro:IPR029009"
                     /db_xref="UniProtKB/Swiss-Prot:P66774"
BEGIN
        1 MTISVFDLFT IGIGPSSSHT VGPMRAANQF VVALRRRGHL DDLEAMRVDL FGSLAATGAG
       61 HGTMSAILLG LEGCQPETIT TEHKERRLAE IAASGVTRIG GVIPVPLTER DIDLHPDIVL
      121 PTHPNGMTFT AAGPHGRVLA TETYFSVGGG FIVTEQTSGN SGQHPCSVAL PYVSAQELLD
      181 ICDRLDVSIS EAALRNETCC RTENEVRAAL LHLRDVMVEC EQRSIAREGL LPGGLRVRRR
      241 AKVWYDRLNA EDPTRKPEFA EDWVNLVALA VNEENASGGR VVTAPTNGAA GIVPAVLHYA
      301 IHYTSAGAGD PDDVTVRFLL TAGAIGSLFK ERASISGAEV GCQGEVGSAA AMAAAGLAEI
      361 LGGTPRQVEN AAEIAMEHSL GLTCDPIAGL VQIPCIERNA ISAGKAINAA RMALRGDGIH
      421 RVTLDQVIDT MRATGADMHT KYKETSAGGL AINVAVNIVE C
//