LOCUS       SIT98418.1               187 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Intracellular
            protease protein.
ACCESSION   LT708304-53
PROTEIN_ID  SIT98418.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0053"
                     /note="Mb0053, -, len: 187 aa. Equivalent to Rv0052, len:
                     187 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 187 aa overlap). Conserved
                     hypothetical protein, similar to others e.g.
                     AL049587|SC5F2A_30S|T35272 hypothetical protein from
                     Streptomyces coelicolor (211 aa), FASTA scores: opt: 531,
                     E(): 3.4e-29, (49.5% identity in 182 aa overlap);
                     NP_420588.1|NC_002696 ThiJ/PfpI family protein from
                     Caulobacter crescentus (267 aa); etc. Some similarity to
                     Escherichia coli G1100872|thiJ (198 aa), FASTA scores:
                     opt: 178, E(): 6.1e-06, (29.9% identity in 137 aa
                     overlap). Also similar to Rv1930c from Mycobacterium
                     tuberculosis (174 aa). May be a membrane protein. Protein
                     product from Mb0053 detected using shotgun mass
                     spectrometry. Mb0053 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR002818"
                     /db_xref="InterPro:IPR029062"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XU47"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MPSFDVVFVG HRRGEVRSDN AMLGLLCDAA FDELTRPDVV IFPGGIGTRT LIHDQTVLDW
       61 VREAHRHTLL TTSVCTGGLV LAAAGLLNGL TATTHWRVQD LFNSLGARYV PQRVVEHLPE
      121 RVITAAGVSS GIDMGLRLVE LLVSREAAEA SQLMIEYDPQ PPVDAGSLAK ASPATHRLAL
      181 EFYQHRL
//