LOCUS SIT98414.1 822 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE (PEPTIDOGLYCAN TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE (DD-TRANSPEPTIDASE) protein. ACCESSION LT708304-51 PROTEIN_ID SIT98414.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="ponA1" /locus_tag="BQ2027_MB0051" /note="Mb0051, ponA1, len: 680 aa. Equivalent to Rv0050, len: 678 aa, from Mycobacterium tuberculosis strain H37Rv, (99.6% identity in 680 aa overlap). Probable ponA1, penicillin-binding protein (class A), bienzymatic protein with transglycosylase (EC 2.4.2.-) and transpeptidase (EC 3.4.-.-) activities, highly similar to many e.g. NP_302715.1|NC_002677 penicillin-binding protein from Mycobacterium leprae (708 aa); AAB53123.1|L39923 penicillin binding protein from Mycobacterium leprae (686 aa), FASTA scores: (82.3% identity in 679 aa overlap); Q9F9V7|PONA|AAG13121.1|AF165523_1|AF165523 penicillin-binding protein 1 from Mycobacterium smegmatis (715 aa) (see citation below); CAB88838.1|AL353832 probable penicillin-binding protein from Streptomyces coelicolor (756 aa); etc. Also similar to ponA2|Rv3682|MTV025.030 BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B from Mycobacterium tuberculosis (810 aa). BELONGS TO THE TRANSGLYCOSYLASE FAMILY IN THE N-TERMINAL SECTION, AND TO THE TRANSPEPTIDASE FAMILY IN THE C-TERMINAL SECTION. REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, two insertions of 3 bp each (*-tcc, *-cgt) leads to a slightly longer product compared to its homolog in Mycobacterium tuberculosis strain H37Rv (680 aa versus 678 aa). Protein product from Mb0051 detected using SWATH mass spectrometry. Mb0051 found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="GOA:A0A1R3XUS2" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="UniProtKB/TrEMBL:A0A1R3XUS2" BEGIN 1 MNSDGRHHQS SSGAPRGPAN PGQRGQVPPD DRLTAILPPV TDDRSAPHAD SIEAVKAALD 61 GAPPMPPPRD PLEEVTAALA APPGKPPRGD QLGGRRRPPG PPGPPGSSGQ PAGRLPQPRV 121 DLPRVGQINW KWIRRSLYLT AAVVILLLMV TFTMAYLIVD VPKPGDIRTN QVSTILASDG 181 SEIAKIVPPE GNRVDVNLSQ VPMHVRQAVI AAEDRNFYSN PGFSFTGFAR AVKNNLFGGD 241 LQGGSTITQQ YVKNALVGSA QHGWSGLMRK AKELVIATKM SGEWSKDDVL QAYLNIIYFG 301 RGAYGISAAS KAYFDKPVEQ LTVAEGALLA ALIRRPSTLD PAVDPEGAHA RWNWVLDGMV 361 ETKALSPNDR AAQVFPETVP PDLARAENQT KGPNGLIERQ VTRELLELFN IDEQTLNTQG 421 LVVTTTIDPQ AQRAAEKAVA KYLDGQDPDM RAAVVSIDPH NGAVRAYYGG DNANGFDFAQ 481 AGLQTGSSFK VFALVAALEQ GIGLGYQVDS SPLTVDGIKI TNVEGEGCGT CNIAEALKMS 541 LNTSYYRLML KLNGGPQAVA DAAHQAGIAS SFPGVAHTLS EDGKGGPPNN GIVLGQYQTR 601 VIDMASAYAT LAASGIYHPP HFVQKVVSAN GQVLFDASTA DNTGDQRIPK AVADNVTAAM 661 EPIAGYSRGH NLAGGRDSAA KTGTTQFGDT TANKDAWMVG YTPSLSTAVW VGTVKGDEPL 721 VTASGAAIYG SGLPSDIWKA TMDGALKGTS NETFPKPTEV GGYAGVPPPP PPPPSEVPPS 781 ETVIQPTVEI APGITIPIGP PTTITLAPPP PAPPAATPTP PP //