LOCUS       SIT98414.1               822 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN
            POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE
            (PEPTIDOGLYCAN TGASE) + PENICILLIN-SENSITIVE TRANSPEPTIDASE
            (DD-TRANSPEPTIDASE) protein.
ACCESSION   LT708304-51
PROTEIN_ID  SIT98414.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ponA1"
                     /locus_tag="BQ2027_MB0051"
                     /note="Mb0051, ponA1, len: 680 aa. Equivalent to Rv0050,
                     len: 678 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.6% identity in 680 aa overlap). Probable ponA1,
                     penicillin-binding protein (class A), bienzymatic protein
                     with transglycosylase (EC 2.4.2.-) and transpeptidase (EC
                     3.4.-.-) activities, highly similar to many e.g.
                     NP_302715.1|NC_002677 penicillin-binding protein from
                     Mycobacterium leprae (708 aa); AAB53123.1|L39923
                     penicillin binding protein from Mycobacterium leprae (686
                     aa), FASTA scores: (82.3% identity in 679 aa overlap);
                     Q9F9V7|PONA|AAG13121.1|AF165523_1|AF165523
                     penicillin-binding protein 1 from Mycobacterium smegmatis
                     (715 aa) (see citation below); CAB88838.1|AL353832
                     probable penicillin-binding protein from Streptomyces
                     coelicolor (756 aa); etc. Also similar to
                     ponA2|Rv3682|MTV025.030 BIFUNCTIONAL MEMBRANE-ASSOCIATED
                     PENICILLIN-BINDING PROTEIN 1A/1B from Mycobacterium
                     tuberculosis (810 aa). BELONGS TO THE TRANSGLYCOSYLASE
                     FAMILY IN THE N-TERMINAL SECTION, AND TO THE
                     TRANSPEPTIDASE FAMILY IN THE C-TERMINAL SECTION.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, two
                     insertions of 3 bp each (*-tcc, *-cgt) leads to a slightly
                     longer product compared to its homolog in Mycobacterium
                     tuberculosis strain H37Rv (680 aa versus 678 aa). Protein
                     product from Mb0051 detected using SWATH mass
                     spectrometry. Mb0051 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XUS2"
                     /db_xref="InterPro:IPR001264"
                     /db_xref="InterPro:IPR001460"
                     /db_xref="InterPro:IPR012338"
                     /db_xref="InterPro:IPR023346"
                     /db_xref="InterPro:IPR036950"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XUS2"
BEGIN
        1 MNSDGRHHQS SSGAPRGPAN PGQRGQVPPD DRLTAILPPV TDDRSAPHAD SIEAVKAALD
       61 GAPPMPPPRD PLEEVTAALA APPGKPPRGD QLGGRRRPPG PPGPPGSSGQ PAGRLPQPRV
      121 DLPRVGQINW KWIRRSLYLT AAVVILLLMV TFTMAYLIVD VPKPGDIRTN QVSTILASDG
      181 SEIAKIVPPE GNRVDVNLSQ VPMHVRQAVI AAEDRNFYSN PGFSFTGFAR AVKNNLFGGD
      241 LQGGSTITQQ YVKNALVGSA QHGWSGLMRK AKELVIATKM SGEWSKDDVL QAYLNIIYFG
      301 RGAYGISAAS KAYFDKPVEQ LTVAEGALLA ALIRRPSTLD PAVDPEGAHA RWNWVLDGMV
      361 ETKALSPNDR AAQVFPETVP PDLARAENQT KGPNGLIERQ VTRELLELFN IDEQTLNTQG
      421 LVVTTTIDPQ AQRAAEKAVA KYLDGQDPDM RAAVVSIDPH NGAVRAYYGG DNANGFDFAQ
      481 AGLQTGSSFK VFALVAALEQ GIGLGYQVDS SPLTVDGIKI TNVEGEGCGT CNIAEALKMS
      541 LNTSYYRLML KLNGGPQAVA DAAHQAGIAS SFPGVAHTLS EDGKGGPPNN GIVLGQYQTR
      601 VIDMASAYAT LAASGIYHPP HFVQKVVSAN GQVLFDASTA DNTGDQRIPK AVADNVTAAM
      661 EPIAGYSRGH NLAGGRDSAA KTGTTQFGDT TANKDAWMVG YTPSLSTAVW VGTVKGDEPL
      721 VTASGAAIYG SGLPSDIWKA TMDGALKGTS NETFPKPTEV GGYAGVPPPP PPPPSEVPPS
      781 ETVIQPTVEI APGITIPIGP PTTITLAPPP PAPPAATPTP PP
//