LOCUS       SIT98408.1               180 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 Transcriptional
            regulator, PadR family protein.
ACCESSION   LT708304-48
PROTEIN_ID  SIT98408.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0048C"
                     /note="Mb0048c, -, len: 180 aa. Equivalent to Rv0047c,
                     len: 180 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 180 aa overlap). Conserved
                     hypothetical protein, equivalent to NP_302717.1|NC_002677
                     conserved hypothetical protein from Mycobacterium leprae
                     (180 aa). Also showing strong similarity to other
                     hypothetical proteins e.g. AL049826|SCH24_22|T36587 from
                     Streptomyces coelicolor (225 aa), FASTA scores: opt: 583,
                     E(): 9e-31, (51.4% identity in 177 aa overlap); etc. Some
                     similarity to Rv1176c from Mycobacterium tuberculosis and
                     to P94443|YFIO from Bacillus subtilis (182 aa), FASTA
                     scores: E(): 0.00066, (24.9% identity in 177 aa overlap).
                     Also some similarity to G1163121 MITHRAMYCIN RESISTANCE
                     DETERMINANT, ATP-BINDING PROTEIN (219 aa), FASTA scores:
                     opt: 143, E(): 0.0091, (29.4% identity in 180 aa overlap).
                     Protein product from Mb0048c detected using shotgun mass
                     spectrometry and SWATH mass spectrometry. Mb0048c found to
                     be expressed during exponential growth in Sauton's minimal
                     media by RNA-sequencing."
                     /db_xref="InterPro:IPR005149"
                     /db_xref="InterPro:IPR036388"
                     /db_xref="InterPro:IPR036390"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XWC5"
BEGIN
        1 MLELAILGLL IESPMHGYEL RKRLTGLLGA FRAFSYGSLY PALRRMQADG LIAENAAPAG
       61 TPVRRARRVY QLTDKGRRRF GELVADTGPH NYTDDGFGVH LAFFNRTPAE ARMRILEGRR
      121 RQVEERREGL REAVARASSS FDRYTRQLHQ LGLESSEREV KWLNELIAAE RAAPNPAEQT
//