LOCUS SIT98408.1 180 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 Transcriptional regulator, PadR family protein. ACCESSION LT708304-48 PROTEIN_ID SIT98408.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB0048C" /note="Mb0048c, -, len: 180 aa. Equivalent to Rv0047c, len: 180 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 180 aa overlap). Conserved hypothetical protein, equivalent to NP_302717.1|NC_002677 conserved hypothetical protein from Mycobacterium leprae (180 aa). Also showing strong similarity to other hypothetical proteins e.g. AL049826|SCH24_22|T36587 from Streptomyces coelicolor (225 aa), FASTA scores: opt: 583, E(): 9e-31, (51.4% identity in 177 aa overlap); etc. Some similarity to Rv1176c from Mycobacterium tuberculosis and to P94443|YFIO from Bacillus subtilis (182 aa), FASTA scores: E(): 0.00066, (24.9% identity in 177 aa overlap). Also some similarity to G1163121 MITHRAMYCIN RESISTANCE DETERMINANT, ATP-BINDING PROTEIN (219 aa), FASTA scores: opt: 143, E(): 0.0091, (29.4% identity in 180 aa overlap). Protein product from Mb0048c detected using shotgun mass spectrometry and SWATH mass spectrometry. Mb0048c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/TrEMBL:A0A1R3XWC5" BEGIN 1 MLELAILGLL IESPMHGYEL RKRLTGLLGA FRAFSYGSLY PALRRMQADG LIAENAAPAG 61 TPVRRARRVY QLTDKGRRRF GELVADTGPH NYTDDGFGVH LAFFNRTPAE ARMRILEGRR 121 RQVEERREGL REAVARASSS FDRYTRQLHQ LGLESSEREV KWLNELIAAE RAAPNPAEQT //