LOCUS       SIT98407.1               367 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 MYO-
            INOSITOL-1-PHOSPHATE SYNTHASE INO1 (Inositol 1-phosphate
            synthetase) (D-glucose 6-phosphate cycloaldolase) (Glucose
            6-phosphate cyclase) (Glucocycloaldolase) protein.
ACCESSION   LT708304-47
PROTEIN_ID  SIT98407.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="ino1"
                     /locus_tag="BQ2027_MB0047C"
                     /standard_name="tbINO"
                     /note="Mb0047c, ino1, len: 367 aa. Equivalent to Rv0046c,
                     len: 367 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (99.7% identity in 367 aa overlap). ino1 (alternate gene
                     name: tbINO), myo-inositol-1-phosphate synthase (EC
                     5.5.1.4) (see citations below), equivalent to
                     Q57240|Y046_MYCLE|U00015_14|G466956|B1620_F3_113
                     HYPOTHETICAL 40.3 KDA PROTEIN from Mycobacterium leprae
                     (369 aa), FASTA scores: opt: 2221, E(): 0, (91.8% identity
                     in 366 aa overlap). N-terminus similar to N-terminus of
                     myo-inositol-1-phosphate synthases e.g. INO1_SPIPO|P42803
                     myo-inositol-1-phosphate synthase (510 aa), FASTA scores:
                     opt: 144, E(): 0.021, (25.2% identity in 365 aa overlap);
                     CAC21218.1|AJ401007 myo-inositol 1P synthase from
                     Thermotoga sp. SG1 (335 aa); etc. Also highly similar to
                     other hypothetical proteins e.g. AL049826|SCH24_21c
                     hypothetical protein from Streptomyces coelicolor (360
                     aa), FASTA scores: opt: 1790, E(): 0, (77.8% identity in
                     360 aa overlap); AE000881_1 conserved protein from M.
                     thermoautotrophicus (368 aa); etc. Protein product from
                     Mb0047c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb0047c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:P59967"
                     /db_xref="InterPro:IPR002587"
                     /db_xref="InterPro:IPR013021"
                     /db_xref="InterPro:IPR017815"
                     /db_xref="InterPro:IPR036291"
                     /db_xref="UniProtKB/Swiss-Prot:P59967"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MSEHQSLPAP EASTEVRVAI VGVGNCASSL VQGVEYYYNA DDTSTVPGLM HVRFGPYHVR
       61 DVKFVAAFDV DAKKVGFDLS DAIFASENNT IKIADVAPTN VIVQRGPTLD GIGKYYADTI
      121 ELSDAEPVDV VQALKEAKVD VLVSYLPVGS EEADKFYAQC AIDAGVAFVN ALPVFIASDP
      181 VWAKKFTDAG VPIVGDDIKS QVGATITHRV LAKLFEDRGV QLDRTMQLNV GGNMDFLNML
      241 ERERLESKKI SKTQAVTSNL KREFKTKDVH IGPSDHVGWL DDRKWAYVRL EGRAFGDVPL
      301 NLEYKLEVWD SPNSAGVIID AVRAAKIAKD RGIGGPVIPA SAYLMKSPPE QLPDDIARAQ
      361 LEEFIIG
//