LOCUS       SIT98406.1               298 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            HYDROLASE protein.
ACCESSION   LT708304-46
PROTEIN_ID  SIT98406.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0046C"
                     /note="Mb0046c, -, len: 298 aa. Equivalent to Rv0045c, len
                     298 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 298 aa overlap). Possible hydrolase
                     (EC 3.-.-.-), showing similarity with others eg
                     NP_107230.1|NC_002678 putative hydrolase from
                     Mesorhizobium loti (278 aa); CAB56730.1|AL121600 putative
                     hydrolase from Streptomyces coelicolor (302 aa);
                     NP_438361.1|NC_000907 putative esterase/lipase from
                     Haemophilus influenzae Rd (287 aa); etc. Also similar to
                     Mycobacterium tuberculosis proteins Rv3473c, Rv1123c,
                     Rv1938, Rv3617, Rv3670, etc. Protein product from Mb0046c
                     detected using shotgun mass spectrometry and SWATH mass
                     spectrometry. Mb0046c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XU63"
                     /db_xref="InterPro:IPR000073"
                     /db_xref="InterPro:IPR029058"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XU63"
BEGIN
        1 MLSDDELTGL DEFALLAENA EQAGVNGPLP EVERVQAGAI SALRWGGSAP RVIFLHGGGQ
       61 NAHTWDTVIV GLGEPALAVD LPGHGHSAWR EDGNYSPQLN SETLAPVLRE LAPGAEFVVG
      121 MSLGGLTAIR LAAMAPDLVG ELVLVDVTPS ALQRHAELTA EQRGTVALMH GEREFPSFQA
      181 MLDLTIAAAP HRDVKSLRRG VFHNSRRLDN GNWVWRYDAI RTFGDFAGLW DDVDALSAPI
      241 TLVRGGSSGF VTDQDTAELH RRATHFRGVH IVEKSGHSVQ SDQPRALIEI VRGVLDTR
//