LOCUS SIT98403.1 208 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN (PROBABLY MARR-FAMILY) protein. ACCESSION LT708304-43 PROTEIN_ID SIT98403.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /locus_tag="BQ2027_MB0043C" /note="Mb0043c, -, len: 208 aa. Equivalent to Rv0042c, len: 208 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 208 aa overlap). Possible transcriptional regulatory protein, MarR-family, highly similar except in N-terminus to CAC32228.1|AL583926 putative MarR-family regulatory protein from Mycobacterium leprae (243 aa). Also similar in part to others e.g. AB76343.1|AL158061 putative MarR-family transcriptional regulator from Streptomyces coelicolor (163 aa); NP_384406.1|NC_003047 PUTATIVE TRANSCRIPTION REGULATOR PROTEIN from Sinorhizobium meliloti (164 aa); NP_531782.1|NC_003304 transcriptional regulator, MarR family from Agrobacterium tumefaciens (151 aa); etc. Also some similarity to Mycobacterium tuberculosis proteins Rv2327, Rv0880, and Rv1404. Protein product from Mb0043c detected using shotgun mass spectrometry. Mb0043c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing (TPM > 20)." /db_xref="GOA:A0A1R3XU39" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/TrEMBL:A0A1R3XU39" BEGIN 1 MSVVRSIGKK MQRISGPNAL AVKGRPTQVY GHTHVRLDCR FMADSEFTAP EVTQLAEGLH 61 RALSKLISML RRGDPNGAAA GDLTLAQLSI LVTLLDQGPI RMTDLAAHER VRTPTTTVAI 121 RRLEKIGLVK RSRDPSDLRA VLVDITPQGR AVHGESLANR RAALAALLSQ LPRSDLETLR 181 KALAPLERLA SGEPASGPAS NSPARKRA //