LOCUS       SIT98401.1               310 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 SECRETED
            PROLINE RICH PROTEIN MTC28 (PROLINE RICH 28 KDA ANTIGEN)
            protein.
ACCESSION   LT708304-41
PROTEIN_ID  SIT98401.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="mtc28"
                     /locus_tag="BQ2027_MB0041C"
                     /note="Mb0041c, mtc28, len: 310 aa. Equivalent to Rv0040c,
                     len: 310 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 310 aa overlap). mtc28, secreted
                     proline rich 28 kDa antigen protein (has hydrophobic
                     stretch at N-terminus) (see citation below). Highly
                     similar to O33075|PR28_MYCLE|MT10019 Proline rich 28 kDa
                     antigen from Mycobacterium leprae (278 aa), FASTA scores:
                     opt: 1007, E(): 0, (65.0% identity in 257 aa overlap); and
                     Q9CD47|LPQT_MYCLE|NP_301305.1|NC_002677 putative
                     lipoprotein from Mycobacterium leprae (218 aa). C-terminal
                     part very similar to lipoprotein Rv1016c from
                     Mycobacterium tuberculosis. Mb0041c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR019674"
                     /db_xref="UniProtKB/Swiss-Prot:P0A5Q7"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MIQIARTWRV FAGGMATGFI GVVLVTAGKA SADPLLPPPP IPAPVSAPAT VPPVQNLTAL
       61 PGGSSNRFSP APAPAPIASP IPVGAPGSTA VPPLPPPVTP AISGTLRDHL REKGVKLEAQ
      121 RPHGFKALDI TLPMPPRWTQ VPDPNVPDAF VVIADRLGNS VYTSNAQLVV YRLIGDFDPA
      181 EAITHGYIDS QKLLAWQTTN ASMANFDGFP SSIIEGTYRE NDMTLNTSRR HVIATSGADK
      241 YLVSLSVTTA LSQAVTDGPA TDAIVNGFQV VAHAAPAQAP APAPGSAPVG LPGQAPGYPP
      301 AGTLTPVPPR
//