LOCUS SIT98401.1 310 aa PRT BCT 25-MAY-2020 DEFINITION Mycobacterium tuberculosis variant bovis AF2122/97 SECRETED PROLINE RICH PROTEIN MTC28 (PROLINE RICH 28 KDA ANTIGEN) protein. ACCESSION LT708304-41 PROTEIN_ID SIT98401.1 SOURCE Mycobacterium tuberculosis variant bovis AF2122/97 ORGANISM Mycobacterium tuberculosis variant bovis AF2122/97 Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. REFERENCE 1 AUTHORS Malone K.M. JOURNAL Submitted (06-DEC-2016) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine, University College Dublin, D4, Ireland REFERENCE 2 AUTHORS Malone M K., Farrell D., Malone K. JOURNAL Submitted (15-APR-2020) to the INSDC. School of Veterinary Medicine, Tuberculosis Molecular Microbiology Research Group, University College Dublin, Tuberculosis Molecular Microbiology Research Group, School of Veterinary Medicine,, University College Dublin, D4, Ireland FEATURES Qualifiers source /organism="Mycobacterium tuberculosis variant bovis AF2122/97" /chromosome="Mycobacterium_bovis_AF212297" /isolate="AF2122/97" /mol_type="genomic DNA" /isolation_source="Mycobacterium bovis subsp. bovis strain AF2122/97. This strain is a fully virulent strain that was isolated in 1997 in the UK from a cow suffering necrotic lesions in lung and bronchomediastinal lymph nodes. The strain was also reported to infect and persist in badgers that are considered to be a significant source of bovine infection." /db_xref="taxon:233413" protein /transl_table=11 /gene="mtc28" /locus_tag="BQ2027_MB0041C" /note="Mb0041c, mtc28, len: 310 aa. Equivalent to Rv0040c, len: 310 aa, from Mycobacterium tuberculosis strain H37Rv, (100.0% identity in 310 aa overlap). mtc28, secreted proline rich 28 kDa antigen protein (has hydrophobic stretch at N-terminus) (see citation below). Highly similar to O33075|PR28_MYCLE|MT10019 Proline rich 28 kDa antigen from Mycobacterium leprae (278 aa), FASTA scores: opt: 1007, E(): 0, (65.0% identity in 257 aa overlap); and Q9CD47|LPQT_MYCLE|NP_301305.1|NC_002677 putative lipoprotein from Mycobacterium leprae (218 aa). C-terminal part very similar to lipoprotein Rv1016c from Mycobacterium tuberculosis. Mb0041c found to be expressed during exponential growth in Sauton's minimal media by RNA-sequencing." /db_xref="InterPro:IPR019674" /db_xref="UniProtKB/Swiss-Prot:P0A5Q7" /experiment="experimental evidence, no additional details recorded" BEGIN 1 MIQIARTWRV FAGGMATGFI GVVLVTAGKA SADPLLPPPP IPAPVSAPAT VPPVQNLTAL 61 PGGSSNRFSP APAPAPIASP IPVGAPGSTA VPPLPPPVTP AISGTLRDHL REKGVKLEAQ 121 RPHGFKALDI TLPMPPRWTQ VPDPNVPDAF VVIADRLGNS VYTSNAQLVV YRLIGDFDPA 181 EAITHGYIDS QKLLAWQTTN ASMANFDGFP SSIIEGTYRE NDMTLNTSRR HVIATSGADK 241 YLVSLSVTTA LSQAVTDGPA TDAIVNGFQV VAHAAPAQAP APAPGSAPVG LPGQAPGYPP 301 AGTLTPVPPR //