LOCUS       SIT98377.1               477 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 CONSERVED
            HYPOTHETICAL PROTEIN protein.
ACCESSION   LT708304-27
PROTEIN_ID  SIT98377.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0027"
                     /note="Mb0027, -, len: 477 aa. Equivalent to 5' end of
                     Rv0026, len: 448 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (94.4% identity in 449 aa overlap).
                     Conserved hypothetical protein, showing some similarity to
                     other proteins from Mycobacterium tuberculosis: Rv0025
                     FASTA score: (35.4% identity in 113 aa overlap) and Rv0739
                     (268 aa), FASTA score: (32.4% identity in 142 aa overlap).
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium bovis, a 4
                     bp insertion (*-atcg) leads to a longer protein with a
                     different COOH part compared to its homolog in
                     Mycobacterium tuberculosis strain H37Rv (477 aa versus 448
                     aa). Mb0027 found to be expressed during exponential
                     growth in Sauton's minimal media by RNA-sequencing (TPM >
                     20)."
                     /db_xref="InterPro:IPR019710"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XU28"
BEGIN
        1 MAFDAAMSTH EDLLATIRYV RDRTGDPNAW QTGLTPTEVT AVVTSTTRSE QLDAILRKIR
       61 QRHSNLYYPA PPDREQGDAA RAIADAEAAL AHPNSATAQL DLQVVSAILN AHLKTVEGGE
      121 SLHELQQEIE AAVRIRSDLD TPAGARDFQR FLIGKLKDIR EVVATASLDA ASKSALMAAW
      181 TSLYDASKGD RGDADDRGPA SVGSGGAPAR GAGQQPELPT RAEPDCLLDS LLLEDPGLLA
      241 DDLQVPGGTS AAIPSASSTP SLPNLGGATM PGGGATPALV PGVSAPGGLP LSGLLRGVGD
      301 EPELTDFDER GQEVRDPADY EHSNEPDERR ADDREGADED AGLGKSESPP QAPTTVTLPN
      361 GETVTAASPQ LAAAIKAAAS GTPIADAFQQ QGIAIPLPGT AVANPVDPAR ISAGDVGVFT
      421 DRHALALGPS KALLDGQIQH ISAVRGRNFL GWIHPAATAT APARTEAPTP TRPAAAR
//