LOCUS       SIT98373.1               277 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PUTATIVE
            SECRETED PROTEIN P60-RELATED PROTEIN [FIRST PART] protein.
ACCESSION   LT708304-24
PROTEIN_ID  SIT98373.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0024"
                     /note="Mb0024, -, len: 277 aa. Equivalent to 5' end of
                     Rv0024, len: 281 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (100.0% identity in 192 aa overlap).
                     Putative secreted protein, p60 homologue, similar in part
                     to others and relatives proteins e.g. P60_LISIV|Q01837
                     protein p60 precursor (invasion-associated protein) from
                     Listeria ivanovii (524 aa), FASTA scores: opt: 245, E():
                     1.5e-08, (37.0% identity in 100 aa overlap);
                     CAB92656.1|AL356832 putative NPL/P60 family secreted
                     protein from Streptomyces coelicolor (347 aa); etc.
                     Similar to Mycobacterium tuberculosis proteins Rv1477,
                     Rv1478, Rv1566c, Rv2190c. And several homologues in
                     Streptomyces coelicolor e.g. AL049497|SC6G10_8|T35517
                     probable secreted protein (338 aa), FASTA scores: opt:
                     399, E(): 9.8e-18, (34.9% identity in 292 aa overlap).
                     COULD BELONG TO THE E. COLI NLPC / LISTERIA P60 FAMILY.
                     REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     tuberculosis strain H37Rv, Rv0024 exists as a single gene.
                     In Mycobacterium bovis, a frameshift due to a single base
                     deletion (c-*) splits Rv0024 into 2 parts, Mb0024 and
                     Mb0025. Mb0024 found to be expressed during exponential
                     growth in Sauton's minimal media by RNA-sequencing (TPM >
                     20)."
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XU42"
BEGIN
        1 MNYSEVELLS RAHQLFAGDS RRPGLDAGTT PYGDLLSRAA DLNVGAGQRR YQLAVDHSRA
       61 ALLSAARTDA AAGAVITGAQ RDRAWARRST GTVLDEARSD TTVTAVMPIA QREAIRRRVA
      121 RLRAQRAHVL TARRRARRHL AALRALRYRV AHGPGVALAK LRLPSPSGRA GIAVHAALSR
      181 LGRPYVWGAT GPTSSTVPVW SSGPTPRRVF TWIAPPINRS TRGSRCRAHR SGRAIWSSRT
      241 PGTCSWRSAT IWSSRRPMRA RRFGSARWAT TCRFGDR
//