LOCUS       SIT98371.1               256 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 POSSIBLE
            TRANSCRIPTIONAL REGULATORY PROTEIN protein.
ACCESSION   LT708304-23
PROTEIN_ID  SIT98371.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0023"
                     /note="Mb0023, -, len: 256 aa. Equivalent to Rv0023, len:
                     256 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 256 aa overlap). Possible
                     transcriptional regulator, equivalent to
                     CAB96432.1|AJ251434 hypothetical protein from
                     Mycobacterium avium subsp. paratuberculosis (146 aa).
                     N-terminus showing similarity with other transcriptional
                     regulators e.g. AE0002|ECAE000240_9 from Escherichia coli
                     strain K12 (178 aa), FASTA scores: opt: 149, E(): 0.0048,
                     (33.3% identity in 84 aa overlap); etc. Contains probable
                     helix-turn helix motif from aa 19 to 40 (Score 1615, +4.69
                     SD). Protein product from Mb0023 detected using shotgun
                     mass spectrometry and SWATH mass spectrometry. Mb0023
                     found to be expressed during exponential growth in
                     Sauton's minimal media by RNA-sequencing (TPM > 20)."
                     /db_xref="GOA:P67705"
                     /db_xref="InterPro:IPR001387"
                     /db_xref="InterPro:IPR010982"
                     /db_xref="UniProtKB/Swiss-Prot:P67705"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MSRESAGAAI RALRESRDWS LADLAAATGV STMGLSYLER GARKPHKSTV QKVENGLGLP
       61 PGTYSRLLVA ADPDAELARL IAAQPSNPTA VRRAGAVVVD RHSDTDVLEG YAEAQLDAIK
      121 SVIDRLPATT SNEYETYILS VIAQCVKAEM LAASSWRVAV NAGADSTGRL MEHLRALEAT
      181 RGALLERMPT SLSARFDRAC AQSSLPEAVV AALIGVGADE MWDIRNRGVI PAGALPRVRA
      241 FVDAIEASHD ADEGQQ
//