LOCUS       SIT98365.1               521 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 FIG00824290:
            FHA domain protein protein.
ACCESSION   LT708304-20
PROTEIN_ID  SIT98365.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="fhaA"
                     /locus_tag="BQ2027_MB0020C"
                     /note="Mb0020c, TB39.8, len: 521 aa. Equivalent to
                     Rv0020c, len: 527 aa, from Mycobacterium tuberculosis
                     strain H37Rv, (97.9% identity in 527 aa overlap). TB39.8,
                     conserved hypothetical protein, identified by proteomic
                     study by the Statens Serum Institute, Denmark (spot
                     TB39.8) (see citation below). Highly similar to
                     NP_301148.1|NC_002677 conserved hypothetical protein from
                     Mycobacterium leprae (488 aa); and
                     Z70722|MLCB1770_15|T10015 hypothetical protein from
                     Mycobacterium leprae (463 aa), FASTA scores: opt: 1213,
                     E(): 2.2e-32, (72.3% identity in 506 aa overlap).
                     Alternative start codon in position 24979 has been
                     suggested. REMARK-M.bovis-M.tuberculosis: In Mycobacterium
                     bovis, a 18 bp deletion leads to a shorter product
                     compared to its homolog in Mycobacterium tuberculosis
                     strain H37Rv (521 aa versus 527 aa). Protein product from
                     Mb0020c detected using shotgun mass spectrometry and SWATH
                     mass spectrometry. Mb0020c found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR000253"
                     /db_xref="InterPro:IPR008984"
                     /db_xref="InterPro:IPR022128"
                     /db_xref="InterPro:IPR042287"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XUP2"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MGSQKRLVQR VERKLEQTVG DAFARIFGGS IVPQEVEALL RREAADRIQS LQGNRLLAPN
       61 EYIITLGVHD FEKLGADPEL KSTGFARDLA DYIQEQGWQT YGDVVVRFEQ SSNLHTGQFR
      121 ARGTVNPDVE THPPVIDCAR PQSNHAFGAE PGVAPMSDNS SYRGGQGQGR PDEYYDDRYA
      181 RPQEDPRGGP DPQGGSDPRG GYPPETGGYP PQPGYPRPRH PGQGDYPEQI GYPDQGGYPE
      241 QRGYPDQRGH QDQGRGYPDQ GQGGYPPPYE QRPPVSPGPA AGYGAPGYDQ GYRQSGGCGP
      301 SPGGGQPGYG GYGEYGRGPA RHEEGSYVPS GPPGPPEQRP AYPDQGGYDQ GYQQGATTYG
      361 RQDYGGGADY TRYTESPQVP GYAPQGGGYA EPAGRDYDYG QSGAPDYGQP APGGYSGYGQ
      421 GGYGSAGTSV TLQLDDGSGR TYQLREGSNI IGRGQDAQFR LPDTGVSRRH LEIRWDGQVA
      481 LLADLNSTNG TTVNNAPVQE WQLADGDVIR LGHSEIIVRM H
//