LOCUS       SIT98361.1               491 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            PENICILLIN-BINDING PROTEIN PBPA protein.
ACCESSION   LT708304-16
PROTEIN_ID  SIT98361.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /gene="pbpA"
                     /locus_tag="BQ2027_MB0016C"
                     /note="Mb0016c, pbpA, len: 491 aa. Equivalent to Rv0016c,
                     len: 491 aa, from Mycobacterium tuberculosis strain H37Rv,
                     (100.0% identity in 491 aa overlap). Probable pbpA,
                     penicillin-binding protein, equivalent to
                     NP_301144.1|NC_002677 putative penicillin-binding protein
                     from Mycobacterium leprae (492 aa); and highly similar to
                     MLCB1770_1 penicillin binding protein from Mycobacterium
                     leprae (474 aa), FASTA scores: opt: 2516, E(): 0, (82.4%
                     identity in 472 aa overlap). Also similar to others e.g.
                     T36716 from Streptomyces coelicolor (490 aa);
                     AAF61246.1|AF241575|PbpA from Streptomyces griseus (485
                     aa); NP_347146.1|NC_003030 from Clostridium acetobutylicum
                     (482 aa); E235825|pbpA penicillin binding protein (325
                     aa), FASTA scores: opt: 1618, E(): 0, (78.3% identity in
                     323 aa overlap); etc. And also similar to MTCY270_5 and
                     MTV003_8 from Mycobacterium tuberculosis. Protein product
                     from Mb0016c detected using shotgun mass spectrometry and
                     SWATH mass spectrometry. Mb0016c found to be expressed
                     during exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="GOA:A0A1R3XU21"
                     /db_xref="InterPro:IPR001460"
                     /db_xref="InterPro:IPR012338"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XU21"
                     /experiment="experimental evidence, no additional details
                     recorded"
BEGIN
        1 MNASLRRISV TVMALIVLLL LNATMTQVFT ADGLRADPRN QRVLLDEYSR QRGQITAGGQ
       61 LLAYSVATDG RFRFLRVYPN PEVYAPVTGF YSLRYSSTAL ERAEDPILNG SDRRLFGRRL
      121 ADFFTGRDPR GGNVDTTINP RIQQAGWDAM QQGCYGPCKG AVVALEPSTG KILALVSSPS
      181 YDPNLLASHN PEVQAQAWQR LGDNPASPLT NRAISETYPP GSTFKVITTA AALAAGATET
      241 EQLTAAPTIP LPGSTAQLEN YGGAPCGDEP TVSLREAFVK SCNTAFVQLG IRTGADALRS
      301 MARAFGLDSP PRPTPLQVAE STVGPIPDSA ALGMTSIGQK DVALTPLANA EIAATIANGG
      361 ITMRPYLVGS LKGPDLANIS TTVGYQQRRA VSPQVAAKLT ELMVGAEKVA QQKGAIPGVQ
      421 IASKTGTAEH GTDPRHTPPH AWYIAFAPAQ APKVAVAVLV ENGADRLSAT GGALAAPIGR
      481 AVIEAALQGE P
//