LOCUS       SIT98357.1               262 aa    PRT              BCT 25-MAY-2020
DEFINITION  Mycobacterium tuberculosis variant bovis AF2122/97 PROBABLE
            CONSERVED MEMBRANE PROTEIN protein.
ACCESSION   LT708304-12
PROTEIN_ID  SIT98357.1
SOURCE      Mycobacterium tuberculosis variant bovis AF2122/97
  ORGANISM  Mycobacterium tuberculosis variant bovis AF2122/97
            Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
            Mycobacterium; Mycobacterium tuberculosis complex.
REFERENCE   1
  AUTHORS   Malone K.M.
  JOURNAL   Submitted (06-DEC-2016) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine, University College
            Dublin, D4, Ireland
REFERENCE   2
  AUTHORS   Malone M K., Farrell D., Malone K.
  JOURNAL   Submitted (15-APR-2020) to the INSDC. School of Veterinary
            Medicine, Tuberculosis Molecular Microbiology Research Group,
            University College Dublin, Tuberculosis Molecular Microbiology
            Research Group, School of Veterinary Medicine,, University College
            Dublin, D4, Ireland
FEATURES             Qualifiers
     source          /organism="Mycobacterium tuberculosis variant bovis
                     AF2122/97"
                     /chromosome="Mycobacterium_bovis_AF212297"
                     /isolate="AF2122/97"
                     /mol_type="genomic DNA"
                     /isolation_source="Mycobacterium bovis subsp. bovis strain
                     AF2122/97. This strain is a fully virulent strain that was
                     isolated in 1997 in the UK from a cow suffering necrotic
                     lesions in lung and bronchomediastinal lymph nodes. The
                     strain was also reported to infect and persist in badgers
                     that are considered to be a significant source of bovine
                     infection."
                     /db_xref="taxon:233413"
     protein         /transl_table=11
                     /locus_tag="BQ2027_MB0012"
                     /note="Mb0012, -, len: 262 aa. Equivalent to Rv0012, len:
                     262 aa, from Mycobacterium tuberculosis strain H37Rv
                     (99.2% identity in 262 aa overlap). Probable conserved
                     membrane protein, similar to AL079308|SCH69_23|T36722
                     hypothetical protein from Streptomyces coelicolor (237
                     aa), FASTA scores: opt: 506, E(): 1.9e-25, (39.8% identity
                     in 236 aa overlap). Some similarity to BLU0|1958_35A2
                     DIVIB (fragment) (188 aa), FASTA scores: opt: 204, E():
                     8.9e-07, (35.6% identity in 90 aa overlap); and
                     G1129091|DDS cell division and sporulation protein from
                     Bacillus subtilis (231 aa), FASTA scores: opt: 180, E():
                     3.8e-05, (30.7% identity in 101 aa overlap). Also similar
                     to Rv1823|MTCY1A11_20 from Mycobacterium tuberculosis
                     FASTA score: (30.1% identity in 246 aa overlap); and
                     MTCY1A11_18 FASTA score: (25.5% identity in 235 aa
                     overlap). Contains probable N-terminal signal sequence.
                     Protein product from Mb0012 detected using SWATH mass
                     spectrometry. Mb0012 found to be expressed during
                     exponential growth in Sauton's minimal media by
                     RNA-sequencing."
                     /db_xref="InterPro:IPR010273"
                     /db_xref="UniProtKB/TrEMBL:A0A1R3XU20"
BEGIN
        1 MRLTHPTPCP ENGETMIDRR RSAWRFSVPL VCLLAGLLLA ATHGVSGGTE IRRSDAPRLV
       61 DLVRRAQASV NRLATEREAL TTRIDSVHGR SVDTALAAMQ RRSAELAGVA AMNPVHGPGL
      121 VVTLQDAQRD ANGRFPRDAS PDDLVVHQQD IEAVLNALWN AGAEAIQMQD QRIIAMSIAR
      181 CVGNTLLLNG RTYSPPYTIA AIGDAAAMQA ALAAAPLVTL YKQYVVRFGL GYREEVHPDL
      241 QIVGYADPVR MHFAQPAGPL DY
//